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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900538/
The blood-brain barrier (BBB) poses a unique challenge for drug delivery to the central nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial cells linked together by tight junctions, pericytes, nonfenestrated basal lamina, and astrocytic foot processes.Author: David S. Hersh, Aniket S. Wadajkar, Nathan B. Roberts, Jimena G. Perez, Nina P. Connolly, Victor Fre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751454/
Feb 05, 2008 · The blood–brain barrier (BBB) presents an efficient structural and functional barrier for the delivery of therapeutic agents to the central nervous system (CNS). Due to its unique properties, passage across the BBB often becomes the main limiting factor for the delivery of potential CNS drugs into the brain parenchyma.Author: Jarkko Rautio, Krista Laine, Mikko Gynther, Jouko Savolainen
https://en.wikipedia.org/wiki/Blood-brain_barrier
The blood–brain barrier ( BBB) is a highly selective semipermeable border that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). The blood–brain barrier is formed by endothelial cells of the capillary wall, …Acronym(s): BBB
https://www.sciencedirect.com/science/article/pii/S131901641300042X
Chemical delivery system is defined as one in which a biologically inert molecule is converted into an active drug by a number of steps enhancing the drug delivery at a …Author: Yashumati Ratan Bhardwaj, Ashutosh Pareek, Vivek Jain, Dharma Kishore
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · Research on the blood–brain barrier (BBB) has led to the concept of a complex, dynamic interface between the central nervous system (CNS) and periphery. Banks considers how this new understanding...Author: William A. Banks
https://www.researchgate.net/publication/279408805_Brain_targeting_Drug_Delivery_System_A_Review
targeting, chemical delivery Systems, Drug carrier systems (antibodies, liposomes or Nanoparticles). Among drug carrier. system, Nanoparticles exhibit an impressive attention in the field of targeted drug delivery system because of possessing solid. colloidal particles with a size range between 1- 1000nm.
https://www.sciencedirect.com/science/article/pii/S0168365916303236
The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating blood. The BBB's unique and protective features control brain homeostasis as well …Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://en.wikipedia.org/wiki/Retrometabolic_drug_design
Chemical delivery systems Since their introduction in the early 1980s, CDSs have also generated considerable research work, especially for brain and eye targeting of various therapeutic agents, including those that cannot cross the blood-brain barrier or the blood-retinal barrier on their own.
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