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https://www.sciencedirect.com/science/article/pii/S2211383513000919
The availability of novel lipid excipients with acceptable regulatory and safety profiles coupled with their ability to enhance oral bioavailability has helped in the development of lipid based formulations as a means for drug delivery. Lipid-based drug delivery (LBDD) systems have gained much importance in the recent years due to their ability ...Author: Sandeep Kalepu, Mohanvarma Manthina, Veerabhadhraswamy Padavala
https://www.hindawi.com/journals/jphar/2014/801820/
The principle objective of formulation of lipid-based drugs is to enhance their bioavailability. The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs. Lipid-based ...Author: Kent Jørgensen, Jesper Davidsen, Charlotte Vermehren, Sven Frøkjær, Ole G. Mouritsen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590796/
May 19, 2014 · 2. General Routes of LBDDS. Routes like oral, parenteral, ocular, intranasal, dermal/transdermal, and vaginal can be for the administration of the lipid-based drug delivery systems (LBDDS) [4, 5].However, oral route is the most preferred route because of the properties like noninvasiveness, less expensive, and less prone to side effects, such as injection-site reactions.Author: Kent Jørgensen, Jesper Davidsen, Charlotte Vermehren, Sven Frøkjær, Ole G. Mouritsen
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/lipid-based-drug-delivery-system
A lipid–drug conjugate is one of the most significant approaches for lipid-based drug delivery systems in which the concerned drug is covalently attached with lipids that subsequently improves the drug payload into the system up to as high as 40%–50% w/w.
https://drug-dev.com/lipid-based-delivery-are-lipid-based-drug-delivery-systems-in-your-formulation-toolbox/
ABSTRACT. This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
http://www.americanpharmaceuticalreview.com/Featured-Articles/341191-Why-Consider-a-Lipid-Based-Drug-Delivery-System-LBDDS/
Aug 15, 2017 · Approximately 90 percent of molecules in the discovery pipeline, and approximately 40 percent of drugs with market approval, are poorly water soluble. 2 Advanced delivery technologies, like lipid-based systems, are an alternative solution to safely and effectively deliver the proper therapeutic dose to patients. Unlike conventional tablets or powder-filled capsules, LBDDS can present the drug ...Author: John Lipari
https://www.hindawi.com/journals/ap/2014/574673/
1.1. Lipid Based Vesicular Drug Delivery System. Vesicular drug delivery system can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water.Author: Shikha Jain, Vikas Jain, S. C. Mahajan
https://drug-dev.com/lipid-based-delivery-advanced-lipid-based-drug-delivery-systems-solid-lipid-nanoparticles-nanostructured-lipid-carriers/
Khan A, et al. Int J Nanomedicine. 2013;8:2733. Advanced drug delivery to the lymphatic system: lipid-based nanoformulations. Chih-Hung L, et al. J Food Drug Anal. 2017;25:219. Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers. Mukherjee S, et al. Indian J Pharm Sci. 2009;71 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588690/
Sep 30, 2015 · Topical drug delivery is an area of active research as it provides a convenient and effective dosage form for the treatment of local pathological conditions (dermal drug delivery) or as the site for the administration of systemically active drugs (transdermal drug delivery). Lipid-based vesicles have been used to encapsulate a multitude of ...Author: Susan Hua
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