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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676808/
Considering a future application of these systems for peptide or protein delivery, for most biomacromolecules a parenteral application is inevitable. For that reason, the cytotoxicity of liposomes and lipid nanoparticles is an essential product parameter with regard to a prospective in vivo tolerance evaluation in humans and/or animals.Author: Susana Martins, Bruno Sarmento, Domingos C Ferreira, Eliana B Souto
https://www.nature.com/articles/nbt.3081
Oct 30, 2014 · Efficient protein delivery using cationic lipid transfection reagents enables high efficiency protein-based genome editing in vivo and in vitro. Efficient intracellular delivery of proteins is ...Author: John A. Zuris, John A. Zuris, David B. Thompson, David B. Thompson, Yilai Shu, John P. Guilinger, Jo...
https://www.sciencedirect.com/science/article/pii/S0378517316301120
Lipid-based nanoformulations can meet these requirements. The drug can be adsorbed onto the particle surface or encapsulated within it. ... In terms of protein and peptide delivery, LCNPs have been investigated as carriers for the delivery of insulin (Chung et al., 2002), ...Author: Nada Matougui, Lukas Boge, Anne-Claire Groo, Anita-Monika Umerska, Lovisa Ringstad, Helena Bysell, P...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857543/
For labile, larger proteins and for targeted delivery, lipid particles offer advantages. The particle preparation and loading procedures are mild that can retain biological activity of protein. Lipid particle are generally considered safe based on safety profile of lipid product that are already in the market as they are biodegradable.Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://www.sciencedirect.com/science/article/pii/S0169409X16301004
A variety of lipid-based systems have been explored with regard to their potential for enhancing oral peptide bioavailability. Interestingly, with the exception of the solid lipid nanoparticles (SLN), a common ingredient to most of them is the use of medium chain fatty acids and their glycerides.Author: Zhigao Niu, Inmaculada Conejos-Sánchez, Brendan T. Griffin, Caitriona M. O’Driscoll, María J. Alonso
https://www.researchgate.net/publication/230684242_Oral_delivery_of_peptides_and_proteins_using_lipid-based_drug_delivery_systems
Introduction: In order to successfully develop lipid-based drug delivery systems (DDS) for oral administration of peptides and proteins, it is important to gain an understanding of the colloid ...
https://www.researchgate.net/publication/319122467_An_over_view_Protein_and_peptide_based_drug_delivery
An over view: Protein and peptide based drug delivery. Article (PDF Available) ... Lipid molecules can form other type of particulates . like immune stimulating complexes (ISCOM) and .
https://www.targetingsystems.net/protein-delivery.php
Targetting Systems offers diversely functional reagents for efficient intracellular delivery of active proteins and peptides at cost-effective prices. Learn more about the features and advantages of our innovative protein delivery solutions.
http://www.nature.com/articles/s41598-017-01712-5
May 11, 2017 · To overcome these hurdles and enhance its cellular delivery, various lipid based preparations were then explored in combination with the newly identified optimized stapled peptide 21,22,23,24,25 ...Author: D. Thean, J. S. Ebo, T. Luxton, Xue’Er Cheryl Lee, T. Y. Yuen, F. J. Ferrer, C. W. Johannes, D. P. L...
https://drug-dev.com/lipid-based-delivery-are-lipid-based-drug-delivery-systems-in-your-formulation-toolbox/
ABSTRACT. This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
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