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https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · Fig. 2: Physiological barriers to oral protein and peptide delivery. Fig. 3: Mechanisms of action of materials used for oral drug delivery. Fig. 4: Materials used for oral protein and peptide ...Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
https://www.researchgate.net/publication/286885826_Barriers_to_the_delivery_of_proteins_and_peptides
To study the role of P-glycoprotein (P-gp) in the delivery of colchicine from blood to brain, the pharmacokinetics of colchicine in plasma and brain was studied in the rat by an in vivo method and by the in situ brain perfusion technique. Colchicine was administered intravenously at three doses (1,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Despite the large number of protein therapeutics being discovered each year, oral delivery continues to be a barrier. As a whole, protein and peptide drugs have low bioavailability when administered orally due to problematic barriers including gastrointestinal proteases, the epithelial barrier and efflux pumps.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.sciencedirect.com/science/article/pii/B9780123849649000104
Protein and peptide delivery via oral route is a keen area of research. The main drawbacks that should be considered during development of such a delivery system are barriers to protein absorptions. Such barriers include the mucus barrier, extracellular barriers, enzymatic barriers, and cellular barriers . These barriers restrict the bioavailability of the orally given peptides to less than 1%.Author: Gaurang Patel, Ambikanandan Misra
https://www.future-science.com/doi/full/10.4155/tde-2020-0011
Treatment strategies in clinics have been shifting from small molecules to protein drugs due to the promising results of a highly specific mechanism of action and reduced toxicity. Despite their pr...
https://www.slideshare.net/ManoharKengar/protein-peptide-drug-delivery-system-barrier
Nov 16, 2017 · To cross the capillary endothelium the peptides/proteins must pass between the cells or alternatively transverse across the endothelial cells themselves. Solutes that transverse the endothelial cell membrane may get modified or metabolized by cytoplasmic enzymes. Thus, the endothelial passage poses metabolic or enzymatic barrier to the solution passage. 16/11/2017 16
https://innovareacademics.in/journal/ijcpr/Issues/Vol3Issue2/286.pdf
epithelial cells. The protein or peptide drug must have sufficient water ‐ and lipid‐solubility to pass through these layers. The epithelial tissue represents the next barrier. There are cases where a protein can be absorbed in to these cells by endocytosis, and then
https://advances.sciencemag.org/content/6/14/eaba0145.full
10 days ago · The key factor that limits development of oral delivery of protein and peptide drugs is the existence of multiple physical and biological barriers in the gastrointestinal (GI) tract, including the...
https://www.slideshare.net/BrajeshKumar67/protein-and-peptide-drug
May 24, 2015 · protein and peptide drug delivery system presented by brajesh kumar m. pharm (1st year) pharmaceutics bbau lucknow , 1 Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
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