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https://www.sciencedirect.com/science/article/pii/S0065266005530025
Synthetic vectors based on polycations are promising vectors for gene delivery as they are relatively safe and can be modified by the incorporation of ligands for targeting to specific cell types. However, the levels of gene expression mediated by synthetic vectors are low compared to viral vectors.Author: Martin L. Read, Ann Logan, Leonard W. Seymour
https://www.researchgate.net/publication/7523614_Barriers_to_Gene_Delivery_Using_Synthetic_Vectors
Synthetic vectors based on polycations are promising vectors for gene delivery as they are relatively safe and can be modified by the incorporation of ligands for targeting to specific cell types.
https://www.sciencedirect.com/science/article/abs/pii/S0065266005530025
However, the levels of gene expression mediated by synthetic vectors are low compared to viral vectors. The aim of this chapter is to give an overview of the main barriers that have been identified as limiting gene transfer using polycation‐based synthetic vectors.Author: Martin L. Read, Ann Logan, Leonard W. Seymour
https://www.researchgate.net/publication/11746751_Gene_delivery_with_synthetic_non_viral_carriers
Gene delivery with synthetic (non viral) carriers ... nucleus and a number of biological barriers to effective gene delivery have been identified. ... use of nonviral gene delivery vectors that ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · DNA-based viral vectors for gene delivery systems utilize the viral vectors to deliver genetic materials to the host cells. ... The non-viral chemical methods for gene delivery systems use synthetic or natural compounds to form some particles that facilitate the transfer of genes into the cells. ... The vector overcomes the traditional barriers ...Author: YK Sung, SW Kim
https://www.intechopen.com/books/novel-gene-therapy-approaches/extracellular-and-intracellular-barriers-to-non-viral-gene-transfer
To maximize non-viral gene delivery, levels of expression must be improved. Unfortunately, many extracellular and intracellular barriers (including the extracellular environment, immune scavengers, the cell membrane, endosomal escape, the cytoskeletal network and the nuclear membrane) preclude efficient gene transfer.Author: Lynn F. Gottfried, David A. Dean
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · Synthetic delivery vectors have the potential to address many of the limitations of viral vectors, particularly with respect to safety. For systemic delivery of DNA, both lipid-based vectors and ...Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130907/
Jan 12, 2011 · Indeed, the size of these materials has been shown to result in interesting biological properties, some of which have been successfully applied to gene-delivery processes. The efficiency of the uptake process using non-viral gene-delivery agents depends on the cell type, the target site and the specific carrier composition.Author: Francisco C. Pérez-Martínez, Javier Guerra, Inmaculada Posadas, Inmaculada Posadas, Valentín Ceña, V...
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
There are mainly four barriers that must be overcome by non-viral vectors to achieve successful gene delivery. The vector must be able to tightly compact and protect DNA, target specific cell-surface receptors, disrupt the endosomal membrane, and deliver the DNA cargo to the nucleus [ 115 ].Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
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