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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026551/
May 10, 2014 · Current approaches to enhance CNS delivery of drugs across the brain barriers Cui-Tao Lu , 1 Ying-Zheng Zhao , 2, 3 Ho Lun Wong , 4 Jun Cai , 5 Lei Peng , 2 and Xin-Qiao Tian 1 1 The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, People’s Republic of ChinaAuthor: Cui-Tao Lu, Ying-Zheng Zhao, Ho Lun Wong, Jun Cai, Lei Peng, Xin-Qiao Tian
https://www.medlink.com/article/drug_delivery_to_the_central_nervous_system
The delivery of drugs to the brain is a challenge in the treatment of CNS disorders. The major obstruction to CNS drug delivery is the blood-brain barrier, which limits the access of drugs to the brain substance. In the past, treatment of CNS disease was done mostly with systemically administered drugs. This trend continues.
https://www.pharmafocusasia.com/articles/blood-brain-barrier-and-cns-drug-delivery
Blood-Brain Barrier and CNS Drug Delivery Parvin Zakeri-Milani , Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran. The central nervous system is protected by barriers which control the passage of various chemical substances and microscopic objects, …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913737/
The blood-brain barrier (BBB) is a formidable physical and biochemical barrier to effective drug delivery to the brain, thus limiting the ability to effectively treat central nervous system (CNS) disorders. Within the past decade, intense research efforts have focused on directly targeting the BBB for optimization of drug delivery.Author: Lucy Sanchez-Covarrubias, Lauren M. Slosky, Brandon J. Thompson, Thomas P. Davis, Patrick T. Ronalds...
https://pharmacy.ku.dk/research/cns-drug-delivery-barrier-modelling/
CNS Drug Delivery and Barrier Modelling The CNSBM group work with drug delivery to the brain. We investigate permeation mechanisms of drug compounds and develop artificial brain barriers …
https://www.sciencedirect.com/science/article/abs/pii/S0168365915302923
The blood brain barrier (BBB) poses the greatest challenge to CNS drug delivery and has therefore been a primary focus in the development of novel CNS drug delivery techniques. Limitations set by the BBB include molecule size, polarity, substrate specificity, and active efflux mechanisms. Strategies to overcome these challenges include drug delivery systems in conjunction with other chemical and …
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