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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388327/
The presence of the blood-brain barrier (BBB) is a significant impediment to the delivery of therapeutic agents to the brain for treatment of brain diseases. Focused ultrasound (FUS) has been developed as a non-invasive method for transiently increasing the permeability of the BBB to promote drug delivery to targeted regions of the brain.Author: Alison Burgess, Kullervo H. Hynynen
https://www.sciencedirect.com/science/article/pii/S1359644606004363
The 140 ml volume of CSF in the human brain is completely turned over every 4–5 h, and exits the brain to blood. Moreover, ICV drug delivery to the brain results in high drug exposure at the ependymal surface of the brain, which can cause a subependymal astrogliotic reaction 9, 10.Author: William M. Pardridge
https://www.springer.com/gp/book/9781461351412
The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539316/
The blood-brain barrier (BBB) is the bottleneck in brain drug development and is the single most important factor limiting the future growth of neurotherapeutics. 1 The BBB problem is illustrated in Figure 1, which is a whole body autoradiogram of a mouse sacrificed 30 min after intravenous injection of radiolabeled histamine, a small molecule ...
https://www.futurity.org/blood-brain-barrier-2209852/
New research on the blood-brain barrier and the blood-tumor barrier, which both make cancer drugs less effective, could improve drug delivery. ... anatomic pathology and head of the Comparative ...
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery William A. Banks 1 Nature Reviews Drug Discovery volume 15 , pages 275 – 292 ( 2016 ) Cite this articleAuthor: William A. Banks
https://www.pharmafocusasia.com/articles/blood-brain-barrier-and-cns-drug-delivery
Blood-Brain Barrier and CNS Drug Delivery Parvin Zakeri-Milani , Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran. The central nervous system is protected by barriers which control the passage of various chemical substances and microscopic objects, thereby regulating brain homeostasis.
https://www.worldcat.org/title/blood-brain-barrier-drug-delivery-and-brain-pathology/oclc/852791616
Get this from a library! Blood-Brain Barrier : Drug Delivery and Brain Pathology. [David Kobiler; Shlomo Lustig; Shlomo Shapira] -- These proceedings review and discuss the different aspects of the biology of the Blood-Brain Barrier (BBB) and its involvement in the pathogenesis of brain disorders. The BBB, formed by a complex ...
https://bookspics.com/ebooks/blood-brain-barrier-drug-delivery-and-brain-pathology/
Blood—Brain Barrier: Drug Delivery and Brain Pathology By Joseph D. Fenstermacher, Tavarekere Nagaraja, Kenneth R. Davies (auth.), David Kobiler, Shlomo Lustig, Shlomo Shapira (eds.)
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