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https://www.ncbi.nlm.nih.gov/books/NBK6085/
Bacteria are versatile gene vectors and have been shown to be an effective, safe and inexpensive measure for delivering RNAi to target cells with high selectivity and high specificity. 6 In a concept called transkingdom RNA interference (tkRNAi), it was shown that laboratory strains of E.Coli can be harnessed to produce and deliver therapeutic short interfering RNA. 9Author: Thu Nguyen, Johannes H. Fruehauf
https://onlinelibrary.wiley.com/doi/abs/10.1002/3527600906.mcb.201200030
The first concept, tkRNAi, delivers RNAi effectors into target cells by invasive bacteria which themselves produce therapeutic RNA molecules. The bmRNAi technology utilizes invasive bacteria conveying RNAi effector‐encoding DNA vectors which will act as a matrix for the transcription of these sequences in the target cell by the host cell's transcription machinery.Author: Hermann Lage
http://www.vitherapharma.com/Nguyen_T_Fruehauf_JF_MCDB.pdf
Transkingdom RNA Interference (tkRNAi) is an example of a bacteria-mediated RNAi delivery system that is successful in eliciting efficient gene silencing both in vitro …
https://www.sciencedirect.com/science/article/pii/B9780123942951000056
RNAi effectors delivery by invasive bacteria. (A) By transkingdom RNAi (tkRNAi), bacteria are transformed with an shRNA-encoding vector capable of intrabacterial transcription. In turn, shRNAs are expressed inside the bacterial cells before the vectors are released into the target cell’s cytoplasm.Author: Hermann Lage
https://www.jove.com/video/2099/bacterial-delivery-of-rnai-effectors-transkingdom-rnai
For development of RNA interference (RNAi)-based therapies, a novel strategy was developed, transkingdom RNAi (tkRNAi). This technology uses non-pathogenic bacteria to produce and deliver therapeutic short hairpin RNA …Author: Hermann Lage, Andrea Krühn
https://www.alliedacademies.org/articles/rethinking-delivery-viral-vectors-and-rna-interference-7646.html
Viral vectors are a promising alternative to deliver short hairpin RNA (shRNA) expression cassettes. Many corporate researchers are reluctant to consider viral vectors as a means of delivery due to the poor reputation of gene therapy, as a consequence of adverse events that occurred in early studies.Author: Jens Kurreck
https://www.sciencedirect.com/science/article/pii/S0024320520302988
Bacterial mediated delivery of foreign DNA into mammalian cells employing bacterial vector is termed as bactofection based gene therapy . Most common species of bacteria used for breast cancer vaccination are Salmonella typhimurium [ 79 ], Listeria monocytogenes [ 80 ], Clostridium novyi [ 81 ], Clostridium acetobutylicum , Bifidobacterium longum , Bifidobacterium adolescentis , and Escherichia coli .Author: Balamurugan Shanmugaraj, Lohanathan Bharathi Priya, B. Mahalakshmi, Shanmugam Subbiah, Rouh-Mei Hu, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693226/
Nov 10, 2015 · Xiang’s pioneering study provided the first evidence of transfer of RNAi effector molecules from bacterial vectors to mammals in vivo, and this delivery strategy is termed transkingdom RNAi. Following these studies, Jiang et al. , 2007 [ 105 ] constructed attenuated S. Typhi as an in vivo delivery vector for multidrug-resistance gene (MDR1 ...Author: Ivan Y. C. Lin, Thi Thu Hao Van, Peter M. Smooker
https://www.researchgate.net/publication/285179890_Bacterial_Delivery_of_RNAi_Effectors
In the tkRNAi approach, RNAi effectors are delivered into target cells by invasive bacteria that produce therapeutic RNA molecules. In the bmRNAi approach, RNAi effector-encoding plasmid expression vectors are delivered by invasive bacteria into the target tissue.
https://www.researchgate.net/publication/46580685_Bacterial_vectors_and_delivery_systems_in_cancer_therapy
Bacterial vectors and delivery systems in cancer therapy Gardlik & Fruehauf 703 703 ( A ) Auxotrophic bacteria specifi cally colonize tumors with necrotic and hypoxic ar eas.
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