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http://portal.nifa.usda.gov/web/crisprojectpages/0205277-bacillus-spores-as-vaccine-delivery-systems.html
The advantages of using spores as the vaccine delivery system are 4-fold: (1) Bacterial spores are among the most resistant biological entities known with respect to extreme variations in temperature and hydration; (2) spores of Bacillus subtilis, the bacterium of choice, are known to be harmless when ingested; (3) industrial-scale production of spores is a well-characterized, inexpensive and safe …
https://www.researchgate.net/publication/10745524_Bacillus_spores_for_vaccine_delivery
Recombinant Bacillus subtilis spores were employed as a vaccine delivery system in a heterologous mucosal priming-parenteral boosting vaccination strategy in the mouse model.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249717/
We review here the use of non-recombinant spores of Bacillus subtilis as a delivery system for mucosal immunizations. Spores of B. subtilis are extremely resistant and stable, easy to manipulate and are known to interact with immune cells inducing protective, antigen-specific immune responses [3].Author: Ezio Ricca, Loredana Baccigalupi, Giuseppina Cangiano, Maurilio De Felice, Rachele Isticato
https://www.academia.edu/14169706/Bacillus_spores_for_vaccine_delivery
Keywords: Bacillus subtilis; Bacillus anthracis; Recombinant vaccine 1. The genus Bacillus 2. Bacillus spores as probiotics Bacteria belonging to the genus Bacillus are Gram-positive “Probiotic” is a word derived from the Greek, meaning rods that form a single endospore (spore…
https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-014-0115-2
Aug 12, 2014 · The spore of Bacillus subtilis displaying heterologous antigens has also been considered as a mucosal vaccine vehicle, and shown able to conjugate some advantages of live microrganisms with some of synthetic nanoparticles. Here we review the use of non-recombinant spores of B. subtilis as a delivery system for mucosal immunizations.Author: Ezio Ricca, Loredana Baccigalupi, Giuseppina Cangiano, Maurilio De Felice, Rachele Isticato
https://www.sciencedirect.com/science/article/pii/S0264410X15003515
Bacillus subtilis spores have been successfully used as a probiotic for both humans and animals . Moreover, B. subtilis spores have been successfully employed as vectors for the mucosal delivery of vaccine antigens , , , .Author: Luana R.M.M. Aps, Mariana O. Diniz, Bruna F.M.M. Porchia, Natiely S. Sales, Ana Carolina R. Moreno, ...
https://core.ac.uk/display/53655431
Spores of the genus Bacillus have been used for a long time as probiotics for oral bacteriotherapy both in humans and in animals. Spores are also employed in a veterinary vaccine against anthrax.
https://iai.asm.org/content/82/4/1414
Bacillus subtilis spores have been used as safe and heat-resistant antigen delivery vectors. Nonetheless, the oral administration of spores typically induces weak immune responses to the passenger antigens, which may be attributed to the fast transit through the gastrointestinal tract.Author: Milene Tavares Batista, Renata D. Souza, Juliano D. Paccez, Wilson B. Luiz, Ewerton L. Ferreira, Raf...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993416/
Bacillus subtilis spores have been used as safe and heat-resistant antigen delivery vectors. Nonetheless, the oral administration of spores typically induces weak immune responses to the passenger antigens, which may be attributed to the fast transit through the gastrointestinal tract.Author: Milene Tavares Batista, Renata D. Souza, Juliano D. Paccez, Wilson B. Luiz, Ewerton L. Ferreira, Raf...
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