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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015522/
Introduction. Intra-articular (IA) drug delivery presents many advantages as it offers direct access to the joint space, thus increasing the bioavailability of therapeutic agents at the affected site while reducing systemic exposure, potential side effects and overall cost.Author: Muhammad Farooq Rai, Christine T.N. Pham
https://www.aiche.org/resources/publications/cep/2018/may/designing-drug-delivery-systems-articular-joints
The key obstacle for drug delivery in osteoarthritis is the hostile pharmacokinetics of the joint. Upon injection into the articular joint capsule (), the drug enters synovial fluid, which is subject to rapid physiological turnover (8).The fluid and the drug contained within it are rapidly drained via the venules and lymphatic vessels located in the synovial membrane; hence, most drugs are ...
https://www.ncbi.nlm.nih.gov/pubmed/29792929
To satisfy this unmet medical need, drug delivery systems (DDSs) containing disease-modifying OA drugs (DMOADs) for intra-articular (IA) administration are required to improve the health of OA patients. DDSs should provide controlled and/or sustained drug release, enabling long-term treatment with a reduced number of injections.Author: Pierre Maudens, Olivier Jordan, Eric Allémann
https://www.hindawi.com/journals/jnt/2012/748909/
Local drug delivery strategies may provide for the development of more successful OA treatment outcomes that have potential to reduce local joint inflammation and joint destruction, offer pain relief, and restore patient activity levels and joint function . Intra-articular drug delivery is very useful for treating local disease flareups ...Author: Zhiyue Zhang, Guihua Huang
https://www.sciencedirect.com/science/article/pii/S1359644618300461
Introduction. Osteoarthritis (OA) is the most common type of arthritis and degenerative joint disease. OA is a leading cause of chronic disability and progressively affects cartilage, the synovial membrane, bone and periarticular tissues 1, 2, 3.Knees, hips, fingers and the lower spine region are frequently affected by the occurrence of OA inducing chronic pain, inflammation and stiffness.Author: Pierre Maudens, Olivier Jordan, Eric Allémann
https://www.nature.com/articles/s41584-018-0123-4
Nov 29, 2018 · Intra-articular drug delivery has a number of advantages over systemic administration; however, for the past 20 years, intra-articular treatment options for the management of …Author: Ian A. Jones, Ryan Togashi, Melissa L. Wilson, Nathanael Heckmann, C. Thomas Vangsness
https://www.nature.com/articles/nrrheum.2016.210
Current intra-articular drug delivery methods do not guarantee sufficient drug penetration into cartilage tissue to reach cell and matrix targets at the concentrations necessary to elicit the ...Author: Ambika G. Bajpayee, Alan J. Grodzinsky
https://www.liebertpub.com/doi/abs/10.1089/ten.teb.2009.0447
Nov 07, 2009 · These models, however, also offer the potential to investigate the therapeutic effects of local drug therapy on animal behavior, including pain sensitivity thresholds and locomotion characteristics. Herein, we describe a translational paradigm for the evaluation of an intra-articular drug delivery strategy in a rat OA model.Author: Kyle D. Allen, Samuel B. Adams, Lori A. Setton
https://mitmrsec.mit.edu/sites/default/files/images/Cartilage-targeting%20drug%20delivery-%20can%20electrostatic%20interactions%20help%3F.pdf
rapid drug release within the synovial fluid OPINION Cartilage-targeting drug delivery: can electrostatic interactions help? Ambika G. Bajpayee and Alan J. Grodzinsky Abstract Current intra-articular drug delivery methods do not guarantee sufficient drug penetration …
https://www.tandfonline.com/doi/abs/10.1517/17425247.2014.867325
Jan 09, 2009 · Introduction: Intra-articular (IA) drug delivery is very useful in the treatment of osteoarthritis (OA), the most common chronic joint affliction. However, the therapeutic effect of IA administration depends mostly on the efficacy of drug delivery. Areas covered: The present article reviews the current status of IA therapy for OA treatment as well as its rationale.Author: Mi Lan Kang, Gun-Il Im
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