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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538251/
Nov 16, 2004 · Besides the well known application of microbubbles as contrast agents for diagnostic ultrasound, microbubbles have also been demonstrated an effective technique for targeted delivery of drugs and genes [1-6]. Drugs can be incorporated into the microbubbles in a number of different ways, including binding of the drug to the microbubble shell and attachment of site-specific ligands.Author: Jeane M Tsutsui, Feng Xie, Richard Thomas Porter
https://www.ncbi.nlm.nih.gov/pubmed/17880272
This article provides an overview of related microbubble biofluid mechanics and reviews recent developments in the application of microbubbles for targeted drug delivery. Additionally, related advances in non-bubble microparticles for drug delivery are briefly described in the context of targeted …Author: Joseph L Bull
https://www.nibib.nih.gov/news-events/newsroom/targeted-drug-delivery-microbubbles
Sep 16, 2005 · In current studies, the ultrasound pulse sequence shatters the lipospheres releasing a dye which then adheres to the vessel wall. This approach provides greater accuracy for targeted drug delivery. Future studies will include a drug rather than a dye.Images courtesy of Dr. Katherine Ferrara, University of California-Davis.
https://www.tandfonline.com/doi/abs/10.1517/17425247.4.5.475
The application of microbubbles for targeted drug delivery Joseph L Bull The University of Michigan, Departments of Biomedical Engineering and Surgery, 2142 Lurie Biomedical Engineering Building, 1107 Beal Avenue, Ann Arbor, MI 48109, USA +1 734 647 5395; +1 734 647 4834; [email protected] , PhDAuthor: Joseph L Bull
https://www.researchgate.net/publication/5963374_The_application_of_microbubbles_for_targeted_drug_delivery
Drug delivery with microbubbles and ultrasound is a promising technology and is gaining more and more attention in the field of the targeted drug delivery, especially in cancer drug delivery [6 ...
https://www.nature.com/articles/s41598-020-62410-3
Mar 25, 2020 · Finally, the amounts of forces applied to the microbubbles during targeted drug delivery are given. FSI results Generally, to ensure that the AAA does not rupture, the maximum displacement of the ...
https://www.intechopen.com/books/pharmaceutical-formulation-design-recent-practices/using-microbubbles-as-targeted-drug-delivery-to-improve-aids
Release of drug from microbubbles: microbubbles on application of ultrasound undergo a process known as cavitation. Ultrasound causes the microbubble to burst or break. Ultrasound causes the microbubble to burst or break.Author: Harsha Virsingh Sonaye, Rafik Yakub Shaikh, Chandrashekhar A. Doifode
https://www.sciencedirect.com/science/article/pii/S0720048X01004557
Microbubbles, currently used as contrast agents have potential therapeutic applications. Microbubbles, upon insonation of sufficiently intense ultrasound will cavitate. Cavitation with microbubbles can be used to dissolve blood clots or deliver drugs.Author: Evan C. Unger, Terry Onichi Matsunaga, Thomas McCreery, Patricia Schumann, Robert Sweitzer, Rachel Q...
https://www.researchgate.net/publication/8179626_The_use_of_microbubbles_to_target_drug_delivery
Microbubbles are used to carry a drug or gene until a specific area of interest is reached, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive materials. Furthermore, the ability of albumin-coated microbubbles to adhere to vascular regions...
https://mbi-ctac.sites.medinfo.ufl.edu/files/2017/02/Ultrasound-microbubble-fundamentals-and-gene-delivery-Ferrara-et-al-2007.pdf
ical microbubbles and their application in therapeutic delivery and monitoring. When driven by an ultrasonic pulse, these small gas bubbles oscillate with a wall velocity on the order of tens to hun-dreds of meters per second and can be deflected to a vessel wall or fragmented into particles on the order of nanometers. While
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