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https://journals.sagepub.com/doi/10.1177/106002808501900905
Sep 01, 1985 · A major obstacle in the treatment of ocular infections is the difficulty in obtaining adequate antimicrobial drug concentration at the site of infection. This article reviews the pharmacokinetic principles of ophthalmic drug delivery as it pertains to antimicrobial therapy.Author: Timothy S. Lesar, Richard G. Fiscella
https://www.ncbi.nlm.nih.gov/pubmed/3899562
Antimicrobial drug delivery to the eye. Lesar TS, Fiscella RG. A major obstacle in the treatment of ocular infections is the difficulty in obtaining adequate antimicrobial drug concentration at the site of infection. This article reviews the pharmacokinetic principles of ophthalmic drug delivery as it pertains to antimicrobial therapy.Author: Timothy S. Lesar, Richard G. Fiscella
https://www.sciencedirect.com/science/article/pii/S154201241630115X
Instillation of eye drops is the traditional method of antimicrobial drug delivery to the cornea. Although eye drops allow easy administration by the patient, they usually have poor bioavailability due to rapid nasolacrimal drainage and limited corneal permeability.Author: Ajay Sharma, Jonathan Taniguchi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.researchgate.net/publication/317412025_Emerging_strategies_for_antimicrobial_drug_delivery_to_the_ocular_surface_Implications_for_infectious_keratitis
This review will help pharmaceutical formulators to identify different parts of the eye and the corresponding bacterial infections, ocular barriers to drug delivery, and general consideration when ...
https://www.sciencedirect.com/book/9780323461528/nanostructures-for-antimicrobial-therapy
The successful use of antibiotics is challenged by the rapid emergence of antibiotic resistance and the need for better methods of delivery. To overcome the problem of drug resistance, novel antimicrobial agents are needed to which the clinical isolates cannot easily develop resistance.
http://www.authorstream.com/Presentation/deepscpn-2284224-ocular-drug-delivery-system/
Oct 03, 2014 · INTRODUCTION: Ocular drug delivery system is intended for treatment of various eye disorders. Glaucoma- Timolol, pilocarpine Antimicrobial and Anti-inflamatory drugs- Steroids, Gentamycin Medication for dry eye syndrome HPMC, Ointments
http://www.freepatentsonline.com/y2019/0101669.html
Apr 04, 2019 · Anti Microbial Bandage Contact Lens with Ocular Drug Delivery. The novel device is an antimicrobial bandage contact lens (BCL) that 1) acts as a prophylactic device that prevents microbial infections in an eye using inherently antimicrobial biomaterials with nanotopography, 2) treats existing infection by dispensing antimicrobial medication at ...Author: Albert Yee, Rachel Rosenzweig, Mary Nora Dickson, Elena Liang, Szu-wen Wang
https://www.tandfonline.com/doi/figure/10.1517/17425240902798119
Mar 09, 2018 · For the last three to four decades much emphasis has been placed on drug delivery systems to enhance the ocular penetration of antimicrobial agents. In order to compare ocular drug delivery strategies for ocular infections, the existing studies and methods were revisited using an extensive literature search.Author: Thirumurthy Velpandian
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