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https://www.sciencedirect.com/science/article/pii/S0264410X08012930
Particular challenges for development of veterinary vaccines are the limited fundamental knowledge and reagents to study protective immune responses in veterinary species. Interestingly, the first vaccine ever used became one of the most widely used systems for vaccine antigen delivery, the poxvirus vectors.Author: Alejandro Brun, Emmanuel Albina, Tom Barret, David A.G. Chapman, Markus Czub, Linda K. Dixon, Günthe...
https://www.sciencedirect.com/science/article/pii/S2452072117300667
The development of veterinary vaccines is a challenging task; however, reverse vaccinology is highly promising as a mechanism of veterinary vaccine development. Significant progress has been made in the field of vaccinology during the era of genomics, and next-generation vaccines are set to have an increasing impact on animal health.Author: Sérgio Jorge, Odir Antônio Dellagostin
https://www.researchgate.net/publication/247111064_Antigen_delivery_systems_for_veterinary_vaccine_development_Viral-vector_based_delivery_systems
Request PDF Antigen delivery systems for veterinary vaccine development Viral-vector based delivery systems The recent advances in molecular genetics, pathogenesis and immunology have provided ...
https://www.academia.edu/29065728/Antigen_delivery_systems_for_veterinary_vaccine_development._Viral-vector_based_delivery_systems
Antigen delivery systems for veterinary vaccine development. Viral-vector based delivery systems
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465129/
VACCINE DELIVERY SYSTEMS. Delivery of antigens from oil-based adjuvants such as Freunds[] adjuvant lead to a reduction in the number of doses of vaccine to be administered but due to toxicity concerns like inductions of granulomas at the injection site, such adjuvants are not widely used.FDA approved adjuvants for human uses are aluminium hydroxide and aluminium phosphate in the form of …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534807/
Aug 12, 2015 · In conclusion, in this review we have described the advancement obtained in the recent past on the topic of antigen delivery systems for new vaccine formulations. Studies aimed to compare in controlled assay conditions should be performed in a near future in order to identify the most promising vaccination strategies.Author: Maria Trovato, Piergiuseppe De Berardinis
https://en.wikipedia.org/wiki/Recombinant_vaccine
The development of new delivery systems raises the hope of vaccines that are safer and more efficient to deliver and administer. Lines of research include liposomes and ISCOM (immune stimulating complex). Notable developments in vaccine delivery technologies have included oral vaccines.
https://www.mdpi.com/2076-393X/3/4/930/htm
This issue is crucial in vaccine formulations based on the use of nanoparticles, which can operate both as a delivery system to enhance antigen processing and as an immunostimulatory adjuvant to induce and amplify protective immunity, in part because of their ability to activate the inflammasome and induce the maturation of interleukin 1β.Author: Diana Boraschi, Paola Italiani
https://www.mdpi.com/2076-393X/4/4/48/htm
Furthermore, as shown herein, current vaccine designs include the use of replicative antigen delivery systems, such as attenuated virulent strains, heterologous vectors and DNA vaccines, while non-replicative vaccines include the inactivated whole cell (IWC) and subunit vaccines encoding different S. agalactiae immunogenic proteins.Author: Hetron Mweemba Munang’andu, Joydeb Paul, Øystein Evensen
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003001
We introduce recent developments towards specifically tailored antigens, adjuvants, and delivery systems, and discuss the methodological gaps and lack of knowledge still hampering true rational vaccine design. Finally, we address the potential and limitations of different strategies and technologies for advancing vaccine development.
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