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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207587/
Oct 24, 2018 · Examples of efficient antibody intracellular delivery approaches aimed at specified intracellular compartments are presented in Table Table4, 4, and the advantages and limitations of different approaches are summarized in Table Table5. 5. The ER is very easily targeted by intrabodies, as natural antibodies already contain a signal for secretion ...Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://www.frontiersin.org/articles/10.3389/fphar.2018.01208/full
Oct 24, 2018 · Direct Intracellular Expression. In addition to the physical delivery described above, a well-established straightforward method for intracellular antibody delivery is …Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://www.nature.com/articles/nchem.2779
May 22, 2017 · One of the major obstacles in intracellular targeting using antibodies is their limited release from endosomes into the cytosol. Here we report …Author: Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nak...
https://www.nature.com/articles/s41598-019-55091-0
Dec 10, 2019 · Intracellular delivery of therapeutic antibodies into specific cells using antibody-peptide fusions Skip to main content Thank you for visiting nature.com.Author: Julie Gaston, Nicolas Maestrali, Guilhem Lalle, Marie Gagnaire, Alessandro Masiero, Bruno Dumas, Tar...
https://www.sciencedirect.com/science/article/pii/S0165247802001463
3.2. Intracellular delivery of monoclonal anti-Gag antibody. All of the antibodies were tested on all cell lines for cellular penetration prior to modification. With one exception, 3B3, no staining was seen. The fields were essentially blank, i.e not even surface binding could be seen.Author: Bi-Xing Chen, Bernard F Erlanger
https://clincancerres.aacrjournals.org/content/25/15/4846
Aug 01, 2019 · Experimental Design: We have developed a new targeted nanomedicine based on hyaluronic acid–biocompatible nanocapsules, which allow the intracellular delivery of a specific anti-GSDMB antibody into HER2 breast cancer cells both in vitro and in vivo.Author: Ángela Molina-Crespo, Ana Cadete, David Sarrio, Manuel Gámez-Chiachio, Lidia Martinez, Kinlin Chao, ...
https://www.sciencedirect.com/science/article/pii/S0168365920301541
Improving antibody-based therapies by chemical engineering of antibodies with multimeric cell-penetrating peptides for elevated intracellular delivery. ... Here, we present a technology for elevating the intracellular delivery of antibodies by the conjugation of tetrameric cell-penetrating peptides (tCPPs). The solid phase synthesis of tCPPs ...Author: Max Sauter, Matthias Strieker, Christian Kleist, Artjom Wischnjow, Volker Daniel, Annette Altmann, U...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427876/
Antibodies armed with biologic drugs could greatly expand the therapeutic potential of antibody–drug conjugates for cancer therapy, broadening their application to disease targets currently limited by intracellular delivery barriers.Author: Geoffrey Y Berguig, Anthony J Convertine, Shani Frayo, Hanna B Kern, Erik Procko, Erik Procko, Debas...
https://www.antibodysociety.org/overcoming-antibody-delivery-challenges/
Sep 07, 2017 · The Antibody Society is pleased to invite you to attend its annual Meeting, Antibody Engineering & Therapeutics, which will be held December 11-15, 2017, in San Diego, CA. We will be celebrating the 10th anniversary of the Society at the Society’s Special Session on Thursday December 14, 2017. In session previews that will be posted […]
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30115-0
May 01, 2015 · Antibodies armed with biologic drugs could greatly expand the therapeutic potential of antibody–drug conjugates for cancer therapy, broadening their application to disease targets currently limited by intracellular delivery barriers. Additional selectivity and new therapeutic approaches could be realized with intracellular protein drugs that more specifically target dysregulated pathways in ...Author: Geoffrey Y Berguig, Anthony J Convertine, Shani Frayo, Hanna B Kern, Erik Procko, Erik Procko, Debas...
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