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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207587/
Oct 24, 2018 · Targeted intracellular delivery of antibodies can be aimed at the antigens localized in various intracellular compartments, predominantly the ER, cytosol, and nucleus. Examples of efficient antibody intracellular delivery approaches aimed at specified intracellular compartments are presented in Table Table4, 4 , and the advantages and limitations of different approaches are …Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://www.frontiersin.org/articles/10.3389/fphar.2018.01208/full
Oct 24, 2018 · An efficient cell-specific targeted delivery of antibody for the intracellular antigen of interest from the cell outside requires a stepwise delivery, starting from the specific recognition of the target cells, followed by effective internalization of the construct, with the subsequent endosomal escape to the cytosol and – if necessary – further transport to the required cell compartment (e.g., the nucleus …Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://www.nature.com/articles/s41598-019-55091-0
Dec 10, 2019 · Intracellular delivery of therapeutic antibodies into specific cells using antibody-peptide fusions Skip to main content Thank you for visiting nature.com.Author: Julie Gaston, Nicolas Maestrali, Guilhem Lalle, Marie Gagnaire, Alessandro Masiero, Bruno Dumas, Tar...
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00025
Antibodies, in particular, carry an enormous potential as drugs owing to their remarkable target specificity and low immunogenicity. Although the market has numerous antibodies directed toward extracellular targets, their use in targeting therapeutically important intracellular targets is limited by their inability to cross cellular membrane.Author: Khushboo Singh, Wardah Ejaz, Kingshuk Dutta, S. Thayumanavan
https://clincancerres.aacrjournals.org/content/25/15/4846
Aug 01, 2019 · Experimental Design: We have developed a new targeted nanomedicine based on hyaluronic acid–biocompatible nanocapsules, which allow the intracellular delivery of a specific anti-GSDMB antibody into HER2 breast cancer cells both in vitro and in vivo .Author: Ángela Molina-Crespo, Ana Cadete, David Sarrio, Manuel Gámez-Chiachio, Lidia Martinez, Kinlin Chao, ...
https://www.ncbi.nlm.nih.gov/pubmed/28816384
Oct 02, 2017 · Antibodies are important biopharmaceuticals, but almost all existing antibody-based drugs are limited to targeting antigens located at the cell exterior because of the inability of antibodies to enter the cell interior. Available methods for intracellular delivery of antibodies …Author: Peiyan Yuan, Hailong Zhang, Linghui Qian, Xin Mao, Shubo Du, Changmin Yu, Bo Peng, Shao Q. Yao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764859/
Such an intracellular delivery of antibodies overcomes one of the major challenges in antibody therapy as most antibodies fail to cross cell membrane, widening the horizons of antibody based therapeutics. Similar studies with other therapeutic antibodies could lead to increase in the therapeutic efficiency of antibodies.Author: Ambily Abraham, Usha Natraj, Anjali A. Karande, Ashutosh Gulati, Mathur R. N. Murthy, Sathyabalan Mu...
https://www.frontiersin.org/articles/10.3389/fimmu.2017.01001/full
Aug 18, 2017 · Intracellular Antibodies Intracellular antibodies, which may also be called intrabodies, are antibodies that are produced in the cell, and bind an antigen within the same cell. This is a different delivery strategy from antibodies that are produced extracellularly, and are engineered to then penetrate the cell to access their intracellular target.Author: Iva Trenevska, Demin Li, Alison H. Banham
https://www.nature.com/articles/nchem.2779
May 22, 2017 · One of the major obstacles in intracellular targeting using antibodies is their limited release from endosomes into the cytosol. Here we report an approach to deliver proteins…Author: Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nak...
https://www.sciencedirect.com/science/article/pii/S2162253116300294
The intracellular delivery of biologically active protein represents an important emerging strategy for both fundamental and therapeutic applications. Here, we optimized in vitro delivery of two functional proteins, the β-galactosidase (β-gal) enzyme and the anti-cytokeratin8 (K8) antibody, using liposome-based formulation. The guanidinium ...Author: Benoît Chatin, Benoît Chatin, Mathieu Mével, Mathieu Mével, Julie Devallière, Julie Devallière, Laur...
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