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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891846/
Dec 28, 2013 · II. MicroRNA Therapeutic Approaches. Using high-throughput techniques including miRNA microarrays, unique miRNAs expression profiles are being confirmed to mediate critical pathogenic processes in human disease [38, 41, 42].These findings are rapidly being translated into recommendations targeting miRNA dysregulation.Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
The first strategy developed for systemic delivery of miRNAs into tumors is to synthesize the chemical modified miRNAs or miRNA antagonists such as anti-miRNA oligonucleotides (AMOs) . Such modifications can prevent miRNA antagonists or miRNA mimics …Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S0168365920300705
In tumor lymph nodes, miRNA delivery initially led to a marginal upregulation of cytokines at the earliest time point (0.5 h post treatment) and then to a significant decrease in concentration of IL-1α, IL-1β, IL-2, IL-5, IL-6, IL-12, and IL-17 at 6 h followed by a significant upregulation compared to the control at 24 h.Author: Jennifer C. Wischhusen, Jennifer C. Wischhusen, Sayan Mullick Chowdhury, Taehwa Lee, Huaijun Wang, S...
https://systembio.com/products/miRNA-and-lncRNA-Research-Tools/miRZip-Knockdown-Vectors/miRZip-anti-miRNA-constructs/
Gain a thorough understanding of miR function Permanently knockdown miRs with SBI’s miRZip™ anti-miRNA Expression Lentivectors. Leveraging SBI’s powerful and well-regarded third-generation lentivector technology, each of our miRZip lentivectors expresses a short hairpin RNA (shRNA) that, after processing, preferentially produces an anti-sense miRNA.
https://www.sciencedirect.com/science/article/pii/S0169409X14001033
In vivo miRNA delivery strategies for cancer therapy. A lot of work has been done in exploiting and evaluating the features of tumor and tumor microenvironment to improve RNA delivery. There are two classes of strategies for miRNA delivery — local and systemic delivery. 7.1. Local delivery of miRNAsAuthor: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(19)30184-4.pdf
Original Article Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133 Hongran Yin, 1Gaofeng Xiong, 3Sijin Guo, 1Congcong Xu, Ren Xu, Peixuan Guo, ,2 and Dan Shu 1Center for RNA Nanobiotechnology and Nanomedicine, Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State …
https://www.medscape.com/viewarticle/837884_6
Nov 06, 2019 · In Vivo Delivery of Anti-miRNA . Both anti-miRNA and antisense RNA function through the formation of sense-antisense strands, although the two provide contrasting results.
https://www.researchgate.net/publication/336464563_Efficient_Delivery_of_MicroRNA_miRNA_and_Anti-miRNA_Molecules_using_an_Argininocalix4arene_Macrocycle
Efficient Delivery of MicroRNA (miRNA) and Anti-miRNA Molecules using an Argininocalix[4]arene Macrocycle Article (PDF Available) in Molecular Therapy - Nucleic Acids 18 …
https://pubs.acs.org/doi/10.1021/acsnano.8b07948
Here, we report the targeted delivery of anti-miRNA to cancers via RNA micelles. The phi29 packaging RNA three-way junction (pRNA-3WJ) was used as a scaffold to construct micelles. An oligo with 8nt locked nucleic acid (LNA) complementary to the seed region of microRNA21(miR21) was included in the micelles as an interference molecule for cancer ...Author: Hongran Yin, Hongzhi Wang, Zhefeng Li, Dan Shu, Peixuan Guo
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