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https://www.sciencedirect.com/science/article/pii/S0168365918301202
The clinical success of chimeric antigen receptor (CAR) T cell immunotherapy in treating multiple blood cancers has created a need for efficient methods of ex vivo gene delivery to primary human T cells for cell engineering. Here, we synthesize and evaluate a panel of cationic polymers for gene delivery to both cultured and primary human T cells.Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://www.sciencedirect.com/science/article/pii/S0168365919306108
In general, polymeric delivery systems do not cause an immune response like those seen for viral vectors [23,24] and, due to the development of controlled polymerization techniques, the ease with which polymeric delivery systems can be modified make them a …Author: Anna Kargaard, Anna Kargaard, Joost P.G. Sluijter, Bert Klumperman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523186/
Apr 25, 2019 · Polymeric nanoparticles for the intracellular delivery of DNA and siRNA: (1) complexation of anionic DNA and siRNA with cationic polymers to form polyplexes (2) cellular uptake of polyplexes via different endocytic routes, (3) enclosure and subsequent release of polyplexes from endo-lysosomal compartments, (4) release of free DNA and siRNA from polyplexes leaving behind polymer remnants, …Author: Raj Rai, Saniya Alwani, Ildiko Badea
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831632/
(A) Scheme showing encapsulation, stabilization, and delivery of siRNA in Anionic polymeric nanoplex. The developed siRNA-nanoplex imparts serum stability, avoids in vivo RNase degradation and mediates its cytosolic delivery following the endosomal escape. The endosomal escape leads to a selective siRNA release of loaded siRNA in the cytosolic region, and this phenomenon was facilitated by ...Author: Nidhi Raval, Hardi Jogi, Piyush Gondaliya, Kiran Kalia, Rakesh K. Tekade
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · Dash, P. R. et al. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and …Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://www.nature.com/articles/s41598-019-52390-4
(A) Scheme showing encapsulation, stabilization, and delivery of siRNA in Anionic polymeric nanoplex. The developed siRNA-nanoplex imparts serum stability, avoids in vivo RNase degradation and ...Author: Nidhi Raval, Hardi Jogi, Piyush Gondaliya, Kiran Kalia, Rakesh K. Tekade
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