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https://www.sciencedirect.com/science/article/pii/S0168365911002434
Polymeric micelles are nanoscopic delivery systems formed through self assembly of ABCs. In an aqueous environment, polymeric micelles are characterized with a core–shell architecture, where the hydrophobic core is segregated from the aqueous exterior by a hydrophilic palisade.Author: Xiao-Bing Xiong, Arash Falamarzian, Shyam M Garg, Afsaneh Lavasanifar
https://www.sciencedirect.com/science/article/abs/pii/S0168365911002434
The success in rapid advancement of polymeric micelles from bench to bedside is owed to the rational engineering of core/shell structure so that the polymeric micellar carrier can meet the requirements for optimum delivery of specific drug(s) in certain disease condition(s).Author: Xiao-Bing Xiong, Arash Falamarzian, Shyam M Garg, Afsaneh Lavasanifar
https://www.ncbi.nlm.nih.gov/pubmed/21621570
Oct 30, 2011 · Engineering of amphiphilic block copolymers for polymeric micellar drug and gene delivery. Xiong XB(1), Falamarzian A, Garg SM, Lavasanifar A. Author information: (1)Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada.Author: Xiao-Bing Xiong, Arash Falamarzian, Shyam M Garg, Afsaneh Lavasanifar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446863/
Sep 14, 2012 · In the present work, we synthesized a new amphiphilic comb-shaped copolymer (SP) by conjugating SMA with low molecular weight PEI (PEI 800) for gene delivery. Grafted PEI residues could form stable complexes with DNA due to their strong positive charges, while SMA could reduce the cytotoxicity of the compound by controlling the charge density.Author: Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Shirui Mao, Yaping Li
https://www.researchgate.net/publication/324178135_The_Length_of_Hydrophobic_Chain_in_Amphiphilic_Polypeptides_Regulates_the_Efficiency_of_Gene_Delivery
More importantly, we discovered the length of hydrophobic poly(L-leucine) in amphiphilic polypeptides steadily regulates gene delivery efficiency in two kinds of cells ranking poly…
https://pubs.acs.org/doi/abs/10.1021/acsnano.5b02357
QD–amPEI was optimal for maximal intracellular QD delivery by the large QD payload and the rapid endocytosis kinetics. QD–amPEI platform technology was demonstrated for gene delivery, cell-specific labeling, and ratiometric oxygen sensing. Our QD–amPEI platform has two partitions: positive outer surface and hydrophobic inside pocket.Author: Joonhyuck Park, Junhwa Lee, Jungheon Kwag, Yeonggyeong Baek, Bumju Kim, Calvin Jinse Yoon, Seoyeon B...
https://www.nature.com/articles/3302876
Nov 23, 2006 · These results suggest that the Lipofectin/polymeric micelle system is appropriate for enhancing gene delivery in vivo and that it can be applied as a non-invasive gene therapy …Author: Shanta Bhattarai, S. Y. Kim, K. Y. Jang, H. K. Yi, Y. H. Lee, N. Bhattarai, S. Y. Nam, D. Y. Lee, H....
https://www.researchgate.net/publication/340043216_Novel_amphiphilic_block-copolymer_forming_stable_micelles_and_interpolyelectrolyte_complexes_with_DNA_for_efficient_gene_delivery
Gene therapy is a promising strategy for angiogenesis, but developing gene carriers with low cytotoxicity and high gene delivery efficiency in vivo is a key issue.
https://pubs.acs.org/doi/full/10.1021/acsanm.0c00410
In recent years, polymer nanoassemblies have played an important role in the biopharmaceuticals field. Polymers that form different molecular architectures during a self-assembly process are widely used for a large number of biomedical applications, including as drug carriers, imaging agents, and drug reservoirs, thereby providing a local therapeutic effect.Author: Shivshankar R. Mane, Ashlin Sathyan, Raja Shunmugam
https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
Gene therapy has been at the forefront of drug delivery research for the past three decades. To overcome the barriers of gene delivery, different types of non-viral delivery systems, including polymers, have been developed and advanced to clinical …
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