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https://www.alnylam.com/our-science/
Science That Can Change the World. The discovery of RNA interference (RNAi) has been heralded as a major scientific breakthrough of the kind that happens only once every decade or so, and it represents one of the most promising and rapidly advancing frontiers in biology and drug discovery today.
https://www.alnylam.com/2019/06/21/new-rnai-platform-advances-including-oral-route-of-administration-and-cns-and-ocular-delivery/
Jun 21, 2019 · We presented new advances in our RNAi therapeutics platform, including preclinical results demonstrating oral delivery of GalNAc-conjugated small interfering RNAs (siRNAs) directed to a liver target. The results were presented at the 3rd International Conference on the Long and the Short of Non-Coding RNAs, held...
https://investors.alnylam.com/press-release?id=24656
Vir and Alnylam Expand Collaboration to Advance RNAi Therapeutics for the Treatment of Coronavirus Infection, Including COVID-19. Mar 04, 2020 — Recent Alnylam advances in lung delivery technology suggest possible utility of siRNAs in targeting SARS-CoV-2 and other coronaviruses — Vir to lead development of potential coronavirus RNAi therapeutic candidates, with Alnylam retaining an option ...
https://investors.alnylam.com/press-release?id=23891
Jun 21, 2019 · Alnylam Announces Progress with RNAi Therapeutics Platform, Including Oral Route of Administration and CNS and Ocular Delivery. Jun 21, 2019 −Preclinical Proof of Concept for Oral Delivery Achieved, Demonstrating Robust, Dose-Dependent Silencing of Liver-Expressed Target in Rodents, with Durability Profile Similar to Subcutaneous Administration – ...
https://news.alnylam.com/rnai/articles/harnessing-power-rnaitm-pushing-through-challenges-and-setbacks
We ultimately persisted in improving our delivery technology. One experiment at a time, we evolved the technology that is being used in Alnylam’s investigational medicines today. Now, one patient at a time, positive responses are demonstrating that RNAi technology indeed has the potential to bring about a paradigm shift in medicine.
https://www.nasdaq.com/articles/alnylam-vir-collaborate-on-rnai-therapy-for-coronavirus-2020-03-05
Mar 05, 2020 · Alnylam, Vir Collaborate on RNAi Therapy for Coronavirus ... the companies will leverage Alnylam’s recent advances in lung delivery of novel conjugates of siRNA along with Vir’s expertise in ...
https://www.bioworld.com/articles/433506-in-the-coronavirus-fight-vir-and-alnylam-expand-rnai-agreement
Mar 04, 2020 · The two companies will use Alnylam’s recent work in lung delivery of novel conjugates of siRNA, molecules that mediate RNAi, and San Francisco-based Vir plans to advance one or more siRNAs to treat SARS-CoV-2 and, if possible, other coronaviruses. The hardest part, Maraganore added, is making sure the company can scale up lung delivery.Author: Lee Landenberger
https://www.businesswire.com/news/home/20200304005363/en/%C2%A0Vir-Alnylam-Expand-Collaboration-Advance-RNAi-Therapeutics
Vir and Alnylam Expand Collaboration to Advance RNAi Therapeutics for the Treatment of Coronavirus Infection, Including COVID-19 — Recent Alnylam advances in lung delivery technology suggest ...
https://news.alnylam.com/rnai/articles/building-scale-raising-rnai-therapeutics-infancy
Apr 30, 2018 · When I joined Alnylam in 2004, one of our early challenges was figuring out how to manufacture and deliver RNAi therapeutics for our clinical trials. The task was daunting, as we were among the first to attempt to translate this incredible science into a potential new class of medicines.
https://www.alnylam.de/category/our-approach/delivery-of-rnai-therapeutics/
We are presenting key scientific data on our Enhanced Stabilization Chemistry (ESC)-GalNAc-conjugate delivery platform at the TIDES 2014 meeting held May 12 – 15, 2014 in Providence, Rhode Island. This technology enables subcutaneous dosing of RNAi therapeutics with increased potency and durability, and a wide therapeutic index.
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