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https://phys.org/news/2010-12-oxygen-delivery-allosteric-effectors-human.html
Dec 23, 2010 · Oxygen release from hemoglobin (Hb) is regulated in humans by the allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Increased oxygen release …
https://www.chegg.com/homework-help/questions-and-answers/humans-oxygen-effectively-delivered-tissues-presence-several-allosteric-modulators-name-th-q3720465
In humans, oxygen is effectively delivered to the tissues because of the presence of several allosteric modulators. Name three of these modulators and explain how their presence allows oxygen to be delivered to the tissues.
https://en.wikipedia.org/wiki/Allosteric_modulator
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimulus. Some of them, like benzodiazepines, are drugs. The site that an allosteric modulator binds to (i.e., an allosteric site) is not the same one to which an endogenous agonist of the receptor would bind (i.e., an orthosteric site).
http://journals.lww.com/anesthesia-analgesia/pages/articleviewer.aspx?year=2001&issue=03000&article=00011&type=Fulltext
Allosteric modification of the affinity of hemoglobin for oxygen occurs in a wide variety of physiologic conditions. Both acidosis and increased temperature cause a rightward shift of the oxygen dissociation curve, resulting in an enhanced release of oxygen to the tissues.
https://www.ncbi.nlm.nih.gov/pubmed/18362513
Oxygen delivery enhancers: past, present, and future. Borrione P(1), Mastrone A, Salvo RA, Spaccamiglio A, Grasso L, Angeli A. Author information: (1)Division of Internal Medicine, University of Turin, Orbassano (Turin), Italy. [email protected] In endurance sport the delivery of oxygen to muscles plays a critical role.Author: P. Borrione, A. Mastrone, R. A. Salvo, A. Spaccamiglio, L. Grasso, A. Angeli
https://www.nature.com/articles/srep04601
Apr 08, 2014 · As a paradigm of such allosteric regulation, allostery of human hemoglobin (HbA), which is an oxygen transport protein composed of two α and two β …Author: Masayoshi Takayanagi, Ikuo Kurisaki, Masataka Nagaoka
https://quizlet.com/201841330/chapter-5-protein-function-flash-cards/
- specialized oxygen binding proteins, hemoglobin and myoglobin, to achieve oxygen storage and delivery. Ligand - a small molecule that binds specifically to a larger one; for example, a hormone is the ligand for its specific protein ligand ... Allosteric effectors (modulators) - bind to allosteric proteins at sites separate from the functional ...
https://en.wikipedia.org/wiki/Homotropic_modulation
In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.. The site to which the effector binds is termed the allosteric site or regulatory site.Allosteric sites allow effectors to bind to the protein, often resulting in a conformational change involving protein dynamics.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329591/
Feb 12, 2015 · • Allosteric modulators can provide the option of regulating the drug effects so that it may behave like a dimmer switch rather than acting as an on/off switch by being a complete inhibitor or activator. The following two patent highlights represent some recent examples of new inventions in the emerging field of allosteric modulation.Author: Ahmed F. Abdel-Magid
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/allosteric-modulator
A common question posed in small molecule allosteric modulators programs is: which parameter of an allosteric modulator is most important for in vivo efficacy? Unfortunately, the answer is not clear and may vary by 7TMR, allosteric binding site, allosteric ligand chemotype and therapeutic indication.
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