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https://www.ncbi.nlm.nih.gov/pubmed/3967508
To study the effects of respiratory failure and mechanical ventilation on aerosol delivery to the lungs, we performed nuclear scans after aerosolization of 5 to 9 mCi of Tc-99m diethylenetriamine pentaacetic acid in seven stable, intubated, and mechanically ventilated patients.Author: Neil Macintyre, Robert Silver, Charles Miller, Frank Schuler, R. Coleman
https://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1844-5
Oct 21, 2017 · This systematic review aimed to assess inhaled drug delivery in mechanically ventilated patients or in animal models. Whole lung and regional deposition and the impact of the ventilator circuit, the artificial airways and the administration technique for aerosol delivery were analyzed. In vivo studies assessing lung deposition during invasive mechanical ventilation were selected based on a ...Author: Jonathan Dugernier, Stephan Ehrmann, Stephan Ehrmann, Thierry Sottiaux, Jean Roeseler, Xavier Witteb...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635094/
Feb 24, 2015 · Inhalation therapy in mechanical ventilation. ... With regard to aerosol delivery devices, it was initially believed that lung drug deposition was better with the use of metered dose inhalers (MDIs) than with the use of conventional nebulizers. ... Aerosol delivery in intubated, mechanically ventilated patients. Crit Care Med. 1985; 13 (2):81 ...
https://journals.lww.com/ccmjournal/Abstract/1985/02000/Aerosol_delivery_in_intubated,_mechanically.5.aspx
To study the effects of respiratory failure and mechanical ventilation on aerosol delivery to the lungs, we performed nuclear scans after aerosolization of 5 to 9 mCi of Tc-99m diethylenetriamine pentaacetic acid in seven stable, intubated, and mechanically ventilated patients.
https://www.rtmagazine.com/products-treatment/monitoring-treatment/therapy-devices/aerosol-delivery-mechanical-ventilation/
Jul 02, 2019 · An international survey in 2013 revealed that more than 95% of intensivists use aerosol therapy during mechanical ventilation.[1] This method of drug delivery differs in several ways from inhaled drug delivery administered to spontaneously breathing patients.
https://www.atsjournals.org/doi/full/10.1164/ajrccm.156.1.9610025
Jul 01, 1997 · In mechanically ventilated patients, the efficiency of aerosol delivery to the lower respiratory tract depends on several factors that are not concerns in ambulatory patients ().Important determinants of aerosol deposition in ventilator-supported patients include the delivery system, particle size, characteristics of the ventilator circuit, ventilator mode, and patient-related factors.Author: Rajiv Dhand, Martin J. Tobin
https://www.researchgate.net/publication/236327001_Aerosol_delivery_to_intubated_patients
To reduce the waste of aerosol during expiratory phases in intubated and ventilated patients, ventilators now synchronize aerosol delivery with inspiratory phases, as it is highly recommended in ...
https://journal.chestnet.org/article/S0012-3692(15)43847-4/fulltext
Efficiency of Bronchodilator Aerosol Delivery to the Lungs From the Metered Dose Inhaler in Mechanically Ventilated Patients A Study Comparing Four Different Actuator Devices. ... Appropriate dose response trials will be required to determine the optimum dose of medication for …Author: Hugh D. Fuller, Myrna B. Dolovich, Fiona H. Turpie, Michael T. Newhouse
http://rc.rcjournal.com/content/respcare/49/6/653.full.pdf
On the surface, aerosol delivery to mechanically venti-lated infants presents a relatively simple proposition: smaller patients receive less aerosol than larger pediatric patients or adults, with a lower percent of the initial dose reaching the infants lungs. In fact, the delivery efficiency of nebulizer aerosol is so poor and the inconvenience ...Author: James B Fink
http://rc.rcjournal.com/content/respcare/early/2017/09/05/respcare.05803.full.pdf
of mechanically ventilated patients to achieve meaningful therapeutic effects.17-20,22 Aerosol Delivery Devices in Ventilator-Supported Patients Delivery of aerosols to mechanically ventilated pa-tients differs from that in spontaneously breathing Fig. 1. Effect of albuterol on minimal inspiratory resistance in 12Author: Rajiv Dhand
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