Adenovirus Sirna Delivery

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Adenovirus-delivered siRNA.

    https://www.ncbi.nlm.nih.gov/pubmed/15017078
    Adenovirus-delivered siRNA. Shen C(1), Reske SN. Author information: (1)Department of Nuclear Medicine, University Hospital of Ulm, Germany. RNA interference is the process that double-stranded RNA (dsRNA) induces the homology-dependent degradation of cognate mRNA mediated by 21- to 23-nt small interfering RNA (siRNA).Author: Changxian Shen, Sven N. Reske

Antitumor Activity of an Oncolytic Adenovirus-Delivered ...

    https://cancerres.aacrjournals.org/content/canres/66/19/9736.full.pdf
    small interfering RNAs (siRNA) is hindered by the lackof an optimal delivery platform. We examined the applicability of the replication-competent, oncolytic adenovirus, ONYX-411, to deliver a mutant K-ras siRNA transgene to human cancer cells. Proof-of-principle studies showed an additive tumor growth–inhibitory response through siRNA ...Author: Yu-An Zhang, John Nemunaitis, Shirley K. Samuel, Patrick Chen, Yuqiao Shen, Alex W. Tong

Gene silencing by adenovirus-delivered siRNA - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S0014579303002096
    The availability of high virus titer, infection of a broad spectrum of cell types and independence on active cell division makes adenovirus the vector of choice for siRNA delivery. The human adenovirus serotype 5 was used in our system.Author: Changxian Shen, Andreas K Buck, Xiangwei Liu, Michael Winkler, Sven N Reske

Gene silencing by adenovirus-delivered siRNA.

    https://www.ncbi.nlm.nih.gov/pubmed/12650936
    Mar 27, 2003 · RNA interference is the process that double-stranded RNA induces the homology-dependent degradation of cognate mRNA mediated by 21-23 nucleotide short interfering RNA (siRNA). Here, we describe a simple virus vector for efficient delivery of siRNA into mammalian cells utilizing the well-defined H1-RNA promoter and conventional adenovirus.Author: Changxian Shen, Andreas K Buck, Xiangwei Liu, Michael Winkler, Sven N Reske

Gene silencing by adenovirus-delivered siRNA Request PDF

    https://www.researchgate.net/publication/10843688_Gene_silencing_by_adenovirus-delivered_siRNA
    Gene silencing by adenovirus-delivered siRNA. ... Electroporation-based siRNA delivery is an upcoming therapeutic tool to deliver various siRNAs, both in vitro and in vivo. Discussed in this ...

Delivering siRNA Using Adenoviral Vectors ( Efficiently ...

    http://www.bio-medicine.org/biology-technology/Delivering-siRNA-Using-Adenoviral-Vectors-957-1/
    Delivering siRNA Using Adenoviral Vectors ... Also, adenovirus gene delivery typically results in higher levels of RNA expression. Infection is independent of cell cycle, so adenoviruses can be used to express RNA in both dividing and non-dividing cells. Integration of the adenoviral DNA into the host genome is rare, which means that there is ...

Antitumor Activity of an Oncolytic Adenovirus-Delivered ...

    https://cancerres.aacrjournals.org/content/66/19/9736
    Oct 01, 2006 · Despite successes in animal models, cancer gene therapy with small interfering RNAs (siRNA) is hindered by the lack of an optimal delivery platform. We examined the applicability of the replication-competent, oncolytic adenovirus, ONYX-411, to deliver a mutant K-ras siRNA transgene to human cancer cells.Author: Yu-An Zhang, John Nemunaitis, Shirley K. Samuel, Patrick Chen, Yuqiao Shen, Alex W. Tong

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