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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900005/
Jan 01, 2014 · Introduction. T he adenovirus, an 80–100 nm, nonenveloped, icosahedral capsid, double-stranded DNA virus, is a well-known cause of respiratory tract infections (Ginsberg, 1984).Adenovirus infection in humans usually is mild, but in immunocompromised individuals, it can be life threatening. The adenovirus was first isolated from human adenoids in 1953.Author: Ronald G. Crystal
https://pubs.acs.org/doi/10.1021/acs.nanolett.9b00145
Currently, various oncolytic adenoviruses (OA) are being explored in both preclinical and clinical virotherapy. However, the pre-existing neutralizing antibodies (nAbs) and poor targeting delivery are major obstacles for systemically administered OA. Therefore, we designed bioengineered cell membrane nanovesicles (BCMNs) that harbor targeting ligands to achieve robust antiviral immune ...Author: Peng Lv, Xuan Liu, Xiaomei Chen, Chao Liu, Yang Zhang, Chengchao Chu, Junqing Wang, Xiaoyong Wang, X...
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass. We compared the ability of adeno-associated virus (AAV), adenovirus (Ad), and lentiviral (LV) vectors to deliver genes to renal cells.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://www.ncbi.nlm.nih.gov/pubmed/31904280
Feb 01, 2020 · Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy. Wetzel MD(1), Gao T(2), Stanley K(1), Cooper TK(3), Morris SM Jr(4), Awad AS(1)(2). Author information: (1)Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.Author: Michael D. Wetzel, Ting Gao, Kristen Stanley, Timothy K. Cooper, Sidney M. Jr. Morris, Alaa S. Awad,...
https://www.sciencedirect.com/science/article/pii/S2352304217300272
Adenovirus-mediated gene delivery to mammalian cells. The initial step of adenovirus infection is gaining access to the host cell, and the 12 spikes of the capsid are adhesion receptors, which recognize and bind to specific glycoprotein receptors, such as CAR on the target cell membrane, with the irreversible binding of cell-surface integrins ...Author: Cody S. Lee, Elliot S. Bishop, Ruyi Zhang, Ruyi Zhang, Xinyi Yu, Xinyi Yu, Evan M. Farina, Shujuan Y...
https://www.vigenebio.com/adenovirus-packaging/
Adenovirus is a popular choice for gene delivery applications primarily because of its large packaging capacity, high transgene expression, and ability to infect most cell types. Note: Vigene offers only recombinant adenovirus products and services. We do not work with or sell wild-type adenovirus.
https://www.sciencedirect.com/topics/medicine-and-dentistry/adenovirus-vector
The advantages of adenovirus vectors for delivery of antigens from other pathogens for induction of protective antibody responses are numerous because they interact with innate sensor drive maturation of antigen-presenting cells and do not require addition of adjuvants. E1-deleted adenoviral vectors are safe at immunogenic doses.
https://www.takarabio.com/learning-centers/gene-function/viral-transduction/recombinant-virus-comparison
However, selecting the best viral gene delivery system for your experimental aim can be challenging. Use the tables below to compare the characteristics of lentivirus, retrovirus, adenovirus, and adeno-associated virus (AAV), and select the best viral transduction system for your experiment.
https://www.vigenebio.com/products/adenovirus-products/adenovirus-mirnas
Recombinant viruses are excellent tools for miRNA delivery in both dividing and non-dividing cells. Adenovirus miRNAs in particular are a great choice if you need high transduction efficiency and transient expression. If you are unsure which virus to use, we recommend reading our Viral Delivery Guide.Brand: Vigenebio
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