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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559924/
Jun 25, 2006 · Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier.Author: Sabrina Oliveira, Gert Storm, Raymond M. Schiffelers
https://www.ncbi.nlm.nih.gov/pubmed/15017078
Successful application of RNAi in functional genomics and proteomics, cancer gene therapy, and virus protection depends on the efficient delivery of siRNA into mammalian cells. The availability of high virus titer, infection of a broad spectrum of cell types, and independence on active cell division makes adenovirus the vector of choice for siRNA delivery.Author: Changxian Shen, Sven N. Reske
https://www.thermofisher.com/us/en/home/life-science/rnai/delivering-rnai-to-cells-transfection-and-viral-delivery.html.html
Adenoviral vectors work well for transient delivery in many cell types; however, for some difficult cell lines, such as non-dividing cells and for stable RNAi expression, lentiviral vectors are the best delivery …
http://www.bio-medicine.org/biology-technology/Delivering-siRNA-Using-Adenoviral-Vectors-957-1/
Ambion's new pSilencer adeno 1.0-CMV System combines the advantages of adenoviral vectors with an efficient siRNA expression system (see A Bit About Adenoviral Biology, at right). With pSilencer adeno, you can easily deliver an siRNA expression construct into a variety of mammalian cells and organisms. The modified CMV promoter in the vector efficiently expresses hairpin siRNAs, which elicit gene …
https://www.creative-biolabs.com/gene-therapy/adenoviral-vector-design-for-rnai-delivery.htm
Most adenoviral vectors used in RNAi delivery are derived from human serotypes 2 and 5, the commonly used adenoviruses in gene therapy. In general, siRNA delivery strategy is driven by H1-RNA promoter, while RNA pol II CMV promoter has been demonstrated …
https://academic.oup.com/abbs/article/45/3/213/1129
Jan 07, 2013 · The results showed that the TM4SF4 protein level was significantly reduced 72 and 96 h after virus infection [ Fig. 2 (C) ]. It indicated that the adenovirus-mediated delivery of siRNA targeting TM4SF4 inhibited TM4SF4 expression with high efficiency.Author: Leiming Wang, Jian Feng, Liang Da, Ying Li, Zaiping Li, Mujun Zhao
https://www.nature.com/articles/7701087
Sep 14, 2007 · Sanlioglu, A., Karacay, B., Koksal, I. et al. DcR2 (TRAIL-R4) siRNA and adenovirus delivery of TRAIL (Ad5hTRAIL) break down in vitro tumorigenic potential of prostate carcinoma cells.Author: A D Sanlioglu, B Karacay, B Karacay, I T Koksal, T S Griffith, S Sanlioglu
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