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https://link.springer.com/protocol/10.1007/978-1-61779-370-7_9
Sep 27, 2011 · Heart Gene therapy Adeno-associated virus ... Bekeredjian R. (2012) Adeno-Associated Virus Vector Delivery to the Heart. In: Snyder R., Moullier P. (eds) Adeno-Associated Virus. Methods in Molecular Biology (Methods and Protocols), vol 807. Humana Press. First Online 27 September 2011;Author: Lawrence T. Bish, H. Lee Sweeney, Oliver J. Müller, Raffi Bekeredjian
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655838/
Sep 01, 2017 · Today, adeno-associated viruses (AAV)-based vectors are undoubtedly among the most promising DNA delivery vehicles. Here, AAV biology and technology are reviewed and discussed in the context of their use and efficacy for cardiac gene delivery in large-animal models of heart failure, using different surgical approaches.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962265/
Comparative Cardiac Gene Delivery of Adeno-Associated Virus Serotypes 1–9 reveals that AAV6 Mediates the Most Efficient Transduction in Mouse Heart. Carmela Zincarelli, ... Finally, AAV3 and AAV5 serotypes showed the lowest vector genome copies in the heart (Figure 5). Figure 5. Vector genome copy numbers in selected tissues.Author: Carmela Zincarelli, Stephen Soltys, Giuseppe Rengo M.D., Walter J. Koch, Joseph E. Rabinowitz
https://www.sciencedirect.com/topics/neuroscience/adeno-associated-virus
Adeno-associated viruses enter the cell through integrins, FGF receptor 1 and heparin sulfate proteoglycan receptors. They can travel across the endothelial barrier and reach the cardiomyocytes, which allows myocardial delivery of the adeno-associated virus vector through intracoronary arterial infusion (Lyon et al., 2008). One disadvantage of ...
https://www.sciencedirect.com/science/article/pii/S1443950618301203
C. Zincarelli, S. Soltys, G. Rengo, W.J. Koch, J.E. RabinowitzComparative cardiac gene delivery of adeno-associated virus serotypes 1-9 reveals that AAV6 mediates the most efficient transduction in mouse heartAuthor: Sebastian Bass-Stringer, Bianca C. Bernardo, Bianca C. Bernardo, Clive N. May, Colleen J. Thomas, Co...
https://www.jove.com/video/57560/adeno-associated-virus-mediated-delivery-crispr-for-cardiac-gene
In particular, intravenous and intraperitoneal injection of the recombinant adeno-associated virus (rAAV) serotype rh.74 (rAAVrh.74) has enabled efficient cardiac delivery of the Staphylococcus aureus CRISPR-associated protein 9 (SaCas9) and two guide RNAs (gRNA) to delete a genomic region with a mutant codon in exon 23 of mouse Dmd gene. This ...Author: Li Xu, Yandi Gao, Yeh Siang Lau, Renzhi Han
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.114.302331
The use of vectors based on the small parvovirus adeno-associated virus has gained significant momentum during the past decade. Their high efficiency of transduction of postmitotic tissues in vivo, such as heart, brain, and retina, renders these vectors extremely attractive for several gene therapy applications affecting these organs.Author: Serena Zacchigna, Lorena Zentilin, Mauro Giacca
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(19)30034-6
Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue. ... Adeno-associated virus (AAV) has emerged as a promising gene delivery vector because of its non-pathogenicity, simple structure and genome, and low immunogenicity compared to other viruses. However, its adoption as a safe and effective delivery ...Author: Caitlin M. Guenther, Mitchell J. Brun, Antonette D. Bennett, Michelle L. Ho, Weitong Chen, Banghe Zh...
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.313811
Adeno-associated virus (AAV) is widely used as a gene transfer vector in biomedical and gene therapy studies. 5 AAV serotype 9 (AAV9) can efficiently transduce cardiac myocytes, among other cell and tissue types. 6 AAV9 can package sequences up to 4.7 kb that may include a tissue-specific promoter that drives gene expression in the transduced ...Author: Li Ni, Larry Scott, Hannah M Campbell, Xiaolu Pan, Katherina M Alsina, Julia O Reynolds, Leonne E Ph...
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