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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680553/
Jul 15, 2019 · This editorial is an introduction to the special issue entitled Transmucosal Absorption Enhancers in the Drug Delivery Field (https: ... PEs are commonly tested for nasal delivery of larger peptides and proteins (e.g., insulin, human growth hormone, interferon).Author: Sam Maher, Luca Casettari, Lisbeth Illum
https://www.ncbi.nlm.nih.gov/pubmed/14531723/
This paper describes the basic concepts for the transmucosal delivery of drugs, and in particular the use of the nasal route for delivery of challenging drugs such as polar low-molecular-weight drugs and peptides and proteins. Strategies for the exploitation of absorption enhancers for the ...Author: Stanley S. Davis, Lisbeth Illum
https://link.springer.com/article/10.2165/00003088-200342130-00003
Sep 13, 2012 · Methods for assessing irritancy and damage to the nasal membrane from the use of absorption enhancers are also described. Finally, the mucosal use of absorption enhancers (chitosan) for the improved nasal delivery of vaccines is reported with reference to recent phase I/II clinical studies.Author: Stanley S. Davis, Lisbeth Illum
https://www.mdpi.com/1999-4923/11/3/113/pdf
no absorption enhancers for pulmonary drug administration on the market, quite a few appear to be at the threshold of becoming products for nasal administration. This review critically assesses advances in the field of absorption enhancers for nasal and pulmonary drug administration. The various agents used to increase the absorption of poorlyAuthor: Maliheh Ghadiri, Paul M. Young, Daniela Traini
https://www.sciencedirect.com/science/article/pii/0168365994900809
The potential of cyclodextrins, in particular dimethyl-β-cyclodextrin (DMβCD), as absorption enhancers was investigated for the nasal absorption of two peptide drugs: an ACTH (4–9) hexapeptide analogue and the polypeptide hormone, insulin.Author: J.Coos Verhoef, Nicolaas G.M. Schipper, Stefan G. Romeijn, Frans W.H.M. Merkus
https://www.researchgate.net/publication/9060705_Absorption_Enhancers_for_Nasal_Drug_Delivery
The absorption-promoting capacity of various permeation enhancers in the intranasal delivery of certain therapeutics has been demonstrated in various studies [101][102][103], while a comprehensive ...
https://www.sciencedirect.com/science/article/pii/S0378517306006120
In the present study, several nasal absorption enhancers, used in metoclopramide hydrochloride (MCP HCl) nasal solutions, have been screened for their possible damaging effect in the in vitro human erythrocytes lysis experiment. Moreover, the in vivo leaching of biological markers from the rat nasal epithelium was used as a quantitative assessment for possible nasal mucosal irritation whereby ...Author: N.M. Zaki, N.D. Mortada, G.A.S. Awad, S.S. Abd ElHady
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