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https://www.leadingedgeonly.com/innovation/view/ablation-for-drug-delivery
Summary This thermal skin ablation drug delivery system is a high speed, precise delivery method that enables the improved penetration and permeation of drugs up to a 1000 fold compared to other techniques. Current methods for drug delivery include mechanical and thermal disruption of the skin.
https://www.sciencedaily.com/releases/2017/07/170727102917.htm
Jul 27, 2017 · The researchers used a combination of transparent gel patches, gold nanorods, and near-infrared (NIR) light to create a unique thermal ablation system for transdermal drug delivery. They added fluorescently labeled ovalbumin (FITC-OVA) to the patches to determine the extent...
https://www.tandfonline.com/doi/abs/10.1080/17425247.2019.1649655
The enhancement mechanisms of laser-assisted drug permeation are the direct ablation of the superficial skin, optical breakdown by a photomechanical wave, and a photothermal effect. Areas covered: This review describes the development of laser-assisted drug delivery in the recent 5 years. This review systematically introduces the concepts and enhancement mechanisms of the technique, highlighting the potential of the laser approach for increasing drug …Author: Chien-Yu Hsiao, Shih-Chun Yang, Ahmed Alalaiwe, Jia-You Fang
https://www.degruyter.com/view/j/plm.2013.2.issue-4/plm-2013-0028/plm-2013-0028.xml?lang=en
Nov 01, 2013 · Drugs/compounds used for transdermal delivery by laser ablation. Dextran, a hydrophilic macromolecular model drug, was used to evaluate the skin permeation. By using a laser with a fluence above 1.7 J/cm 2, the transdermal transport of FDs with MWs ranging from 4.4 kDa to 77 kDa was significantly enhanced.Author: Yajuan Li, Liangran Guo, Wei Lu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211420/
Dec 04, 2007 · A mathematical model of drug transport provides an ideal strategy to optimize intratumoral drug delivery implants to supplement radiofrequency (RF) ablation for tumor treatment. To simulate doxorubicin transport in non-ablated and ablated liver tumors, a one-dimensional, cylindrically symmetric transport model was generated using a finite element method (FEM).Author: Brent D. Weinberg, Brent D. Weinberg, Ravi B. Patel, Agata A. Exner, Gerald M. Saidel, Jinming Gao
https://www.sciencedirect.com/science/article/pii/S0142961213014737
At animal level, hematoporphyrin-based drug delivery system possessed an excellent tumor targeting property and efficient tumor ablation. It has been well documented that particles at nanoscales accumulate in tumor sites by enhanced permeability and retention effect [25] .Author: Yu Ren, Ruirui Wang, Yang Liu, Hua Guo, Xuan Zhou, Xubo Yuan, Chaoyong Liu, Jianguo Tian, Haifang Yi...
https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201602339
Sep 13, 2016 · Multitriggered Tumor‐Responsive Drug Delivery Vehicles Based on Protein and Polypeptide Coassembly for Enhanced Photodynamic Tumor Ablation Ning Zhang State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. ChinaAuthor: Ning Zhang, Fenfang Zhao, Qianli Zou, Yongxin Li, Guanghui Ma, Xuehai Yan
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