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https://www.sciencedirect.com/science/article/pii/S014296121000565X
To overcome the cardiotoxicity of doxorubicin, a self-assembled pH/enzyme-responsive system was developed. Cationic gelatin combined polyGC–DOX intercalation tightly to form compact nanoscale complexes (CPX1) which then combined by a pH-sensitive pegylated alginate to form CPX2.Author: Lei Dong, Suhua Xia, Ke Wu, Zhen Huang, Huan Chen, Jiangning Chen, Junfeng Zhang
https://www.researchgate.net/publication/44601500_A_pHEnzyme-responsive_tumor-specific_delivery_system_for_doxorubicin
A pH/Enzyme-responsive tumor-specific delivery system for doxorubicin. To overcome the cardiotoxicity of doxorubicin, a self-assembled pH/enzyme-responsive system was developed. Cationic gelatin combined polyGC-DOX intercalation tightly to form compact nanoscale complexes (CPX1) which then combined by a pH-sensitive pegylated alginate to form CPX2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425417/
Nov 07, 2014 · For example, pH-responsive nanomaterials have been used to design sensitive nano-systems for drug delivery in cancer therapy as they can stabilize the drug at physiological pH and release the drug when the pH trigger point is reached. 14 Due to the lower pH values in the tumor microenviroment compared to normal tissue, pH-responsive nanomaterials are triggered and release their cargoes (e.g. drugs …Author: Quanyin Hu, Prateek S. Katti, Zhen Gu
https://www.deepdyve.com/lp/elsevier/a-ph-enzyme-responsive-tumor-specific-delivery-system-for-doxorubicin-6o0Bx0xnpO
Aug 01, 2010 · A pH/Enzyme-responsive tumor-specific delivery system for doxorubicin Cationic gelatin combined polyGC–DOX intercalation tightly to form compact nanoscale complexes (CPX1) which then combined by a pH-sensitive pegylated alginate to form CPX2.
https://journals.sagepub.com/doi/10.1177/0883911516643219
May 19, 2016 · In this work, pH-sensitive amphiphilic macromolecules are designed to possess good biocompatibility and drug loading while employing an acid-sensitive linkage to trigger drug release at tumor tissues. Specifically, two pH-sensitive amphiphilic macromolecules were synthesized with a hydrazone linkage between the hydrophobic and hydrophilic segments.Author: Li Gu, Li Gu, Ning Wang, Leora M Nusblat, Rose Soskind, Charles M Roth, Kathryn E Uhrich
https://www.sciencedirect.com/science/article/pii/S0378517317305306
Tumor-specific delivery of doxorubicin through conjugation of pH-responsive peptide for overcoming drug resistance in cancer. ... Besides working as targeting moiety in drug delivery system, these peptides conferred other benefits, including ease of synthesis, versatile methods of functionalization, low levels of immunogenicity and good ...Author: Chunlai Feng, Mengjie Rui, Haijun Shen, Yuanrong Xin, Jie Zhang, Jun Li, Lixiang Yue, Wenlong Lai, X...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559238/
Aug 28, 2015 · Enzyme-responsive doxorubicin release from dendrimer nanoparticles for anticancer drug delivery Sang Joon Lee , 1, * Young-Il Jeong , 2, * Hyung-Kyu Park , 3 Dae Hwan Kang , 2, 4 Jong-Suk Oh , 3 Sam-Gyu Lee , 5 and Hyun Chul Lee 3Author: Sang Joon Lee, Young-Il Jeong, Hyung-Kyu Park, Dae Hwan Kang, Jong-Suk Oh, Sam-Gyu Lee, Hyun Chul Le...
https://www.sciencedirect.com/science/article/pii/S0168365918300476
Dong et al. synthesized a pH and enzyme responsive doxorubicin delivery system . The acetic tumor environment exposed the gelatin-DNA-doxorubicin complex to subsequently release doxorubicin by enzymatic degradation of gelatin due to matrix metalloproteinases upregulated in the tumoral ECM.Author: René Raavé, Toin H. van Kuppevelt, Willeke F. Daamen
https://www.sciencedirect.com/science/article/pii/S0939641113002348
Still, a better delivery system is achievable. Thus, the primary objective of this study was to develop a pH-responsive delivery system that was more efficient in selectively delivering DOX to the tumor and more effective at directing DOX away from the heart to decrease its cardiotoxicity.Author: Yanzuo Chen, Wuli Yang, Baisong Chang, Hangting Hu, Xiaoling Fang, Xianyi Sha
https://www.sciencedirect.com/science/article/pii/S0144861713005626
Hyaluronic acid (HA), a naturally biodegradable and linear polysaccharide, has been investigated as an efficient targeting moiety in drug delivery system (Stern, Asari, & Sugahara, 2006), because it can bind to the CD44 receptor which is over-expressed in various specific tissues such as liver, kidney, and most of tumor tissues (Choi et al., 2011, Engstromlaurent et al., 1985).Author: Minghui Xu, Junmin Qian, Aili Suo, Hongjie Wang, Xueqing Yong, Xuefeng Liu, Rongrong Liu
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