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https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021196s009lbl.pdf
The Xyrem Success Program ... hours, turn off your alarm and take your second dose. Dissolve to shot of patient sitting up in bed, drinking first dose, and then laying down. Drink all of the first dose right before bedtime. Because Xyrem is a medicine that produces
XYREM® (sodium oxybate)—Now approved for use in adults and children ages 7 and older to help treat cataplexy and excessive daytime sleepiness (EDS) in narcolepsy. See XYREM® prescribing information & BOXED Warning about serious side effects, CNS depression, misuse and abuse.
https://www.xyrem.com/healthcare-professionals-b/
The process for prescribing XYREM ® has changed: the XYREM Success Program ... Also caution patients against these hazardous activities for at least 6 hours after taking the second nightly dose. Patients should be queried about CNS depression-related events upon initiation of XYREM therapy and periodically thereafter.
https://www.fda.gov/media/90866/download
airplanes, for the first 6 hours after taking a dose of XYREM f. Safe use, handling, and storage of XYREM. iv. That XYREM is medically appropriate for the patient. ... XYREM REMS Program Central ...
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021196Orig1s019lbl.pdf
divided doses: 2.25 g at bedtime and 2.25 g taken 2.5 to 4 hours later (2.1) Titrate to effect in increments of 1.5 g per night at weekly intervals (0.75 g at bedtime and 0.75 g taken 2.5 to 4...
https://www.xyrem.com/xyrem-patient-support-savings
The XYREM Coupon Program can cover monthly out-of-pocket expenses, including co-pays and any plan deductible. Eligible patients can pay no more than $35 dollars per prescription, subject to a maximum annual benefit. The XYREM Coupon Program applies to patients who have provided consent to services offered by JazzCares ® for XYREM.
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