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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835126/
Apr 30, 2009 · To date, bacterial GDVs have been used mainly in cancer gene therapy 25,31,32,33,35 and for DNA vaccination 27,28,29,34 but they have also been used for the treatment of genetic diseases, e.g., cystic fibrosis. 36 Although transgene expression levels have been generally low compared to other delivery methods, work by Zelmer et al. 44 suggests ...Author: Yiqi Seow, Matthew J Wood
https://en.wikipedia.org/wiki/Gene_delivery
Gene delivery is the process of introducing foreign genetic material, such as DNA or RNA, into host cells. Genetic material must reach the nucleus of the host cell to induce gene expression. Successful gene delivery requires the foreign genetic material to remain stable within the host cell and can either integrate into the genome or replicate independently of it.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900005/
Jan 01, 2014 · History. In 2014, the concept of using a modified virus to transfer genes in vivo is standard practice, widely used throughout the biomedical research community. In the late 1980s, however, when laboratories such as ours started thinking about delivering genes in vivo, the concept was new, and the challenge daunting.. We began strategizing how to effectively transfer genes in vivo as a follow ...Author: Ronald G. Crystal
https://www.researchgate.net/publication/257397076_Gene_Transfer_Technologies_and_their_Applications_Roles_in_Human_Diseases
Gene Transfer Technologies and their Applications i n Human Diseases K.H Khan 215 Lysosomal storage disorders comprise a group of more than 50 di fferent diseases (Table 13).
https://www.mayoclinic.org/medical-professionals/physical-medicine-rehabilitation/news/new-progress-in-development-of-gene-therapy-for-arthritis/mac-20479901
However, the overriding issue was safety, especially because viruses were used as the delivery vehicles and arthritis is not life-threatening. Dr. Evans and his colleagues worked through these issues, and in a 2005 article published in the Proceedings of the National Academy of Sciences, they described the world's first gene transfer to a human ...
https://www.hindawi.com/journals/isrn/2013/397243/
The majority of viral vectors currently used possess modest cargo capability (up to 40 kb) being based on retroviruses, lentiviruses, adenoviruses, and adenoassociated viruses. These vectors have made the most rapid transition from laboratory to clinic because their small genomes have simplified their characterization and modification. However, there is now an increasing need both in ...Author: Filip Lim
https://www.sciencedirect.com/science/article/pii/S0378517313010351
Gene therapy is a promising new technique for treating many serious incurable diseases, such as cancer and genetic disorders. The main problem limiting the application of this strategy in vivo is the difficulty of transporting large, fragile and negatively charged molecules like DNA into the nucleus of the cell without degradation. The key to success of gene therapy is to create safe and ...Author: D. Ibraheem, A. Elaissari, H. Fessi
http://www.genecure.com/technology.html
In either case, gene transfer technologies can be used to deliver a therapeutic gene into patients. For human clinical applications, gene transfer technologies must be designed that are capable of efficiently delivering genes into primary human cells without harming the recipient.
https://www.sciencedirect.com/science/article/pii/S0168365918301202
The clinical success of chimeric antigen receptor (CAR) T cell immunotherapy in treating multiple blood cancers has created a need for efficient methods of ex vivo gene delivery to primary human T cells for cell engineering. Here, we synthesize and evaluate a panel of cationic polymers for gene delivery to both cultured and primary human T cells.Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
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