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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483039/
Mar 05, 2015 · Polymeric drug delivery systems have been developed to allow controlled local release of biologically active substances for a variety of conditions. Their primary advantages relate to their ability to achieve high local concentrations of active agents while limiting or eliminating systemic toxicities.Author: Scott D. Wait, Roshan S. Prabhu, Stuart H. Burri, Tyler G. Atkins, Anthony L. Asher
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438887/
Modern advances in drug delivery are now predicated upon the rational design of polymers tailored for specific cargo and engineered to exert distinct biological functions. In this review, we highlight the fundamental drug delivery systems and their mathematical foundations and discuss the physiological barriers to drug delivery.Author: William B. Liechty, David R. Kryscio, Brandon V. Slaughter, Nicholas A. Peppas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401754/
Dec 12, 2018 · Implantation of a drug delivery device close to the site of action may allow reduced systemic exposure and as a result reduce the damage caused to healthy tissue. Some examples of implantable drug delivery devices for the treatment of cancer are shown in Table 2.Author: Sarah A. Stewart, Juan Domínguez-Robles, Ryan F. Donnelly, Eneko Larrañeta
https://www.sciencedirect.com/science/article/pii/B9780128139974000062
Many aspects of polymeric drug delivery have been investigated over the past three decades, and pharmacokinetic and pharmacodynamic models have been developed to enhance our understanding of properties such as polymer degradation and elimination from the body, biocompatibility with the brain parenchyma, and the occurrence of toxicities.Author: Riccardo Serra, Sakibul Huq, Henry Brem, Betty Tyler
https://www.sciencedirect.com/science/article/pii/B9780128136652000132
The concept of implantable drug delivery systems (IDDSs) in modern medicine may be traced to Deansby and Parkes who, in 1938, subcutaneously (SC) implanted compressed pellets of crystalline estrone to study their effect upon castrated male chickens (Kleiner et al., 2014).Folkman and Long pioneered implantable formulations, with drug release rates controlled by a polymeric membrane, in the 1960s.Author: Anoop Kumar, Jonathan Pillai
https://www.sciencedirect.com/science/article/pii/016836599190030H
Journal of Controlled Release, 16 (1991) 53-60 1991 Eisevier Science Publishers B.V. 0168-3659/91/$03.50 ADONIS 016836599100056M 53 COREL 00584 Polymer implants for drug delivery in the brain Robert Langer Department of Chemical Engineering, Massachusetts Institute ofTechnology, Cambridge, Massachusetts, U.S.A. (Accepted November 13, 1990) The delivery of drugs to the brain …Author: Robert Langer
https://www.researchgate.net/publication/319327771_Implantable_drug_delivery_systems_An_Overview
Implantable drug delivery systems offer physicians the choice of precision delivery, either locally or into systemic circulation, while guaranteeing optimal dosing over the course of treatment.The ...
https://www.sciencedirect.com/science/article/pii/S2211383514000252
With the advancement of novel drug delivery systems, smart polymeric drug delivery systems provide a link between therapeutic need and drug delivery. This review highlights the current literature and describes the principles and mechanisms of smart materials. Various stimuli are utilized to attain the controlled and site-specific delivery of drug.Author: Honey Priya James, Rijo John, Anju Alex, K.R. Anoop
https://quizlet.com/131984499/implantable-drug-delivery-systems-flash-cards/
Implantable Drug Delivery Systems An implant is a singleunit drug delivery system that has been designed to deliver a drug moiety at a therapeutically desired rate, over a prolonged period of time Patches are for _____ periods of time since they're removable, implants are for _____ periods of time.
https://www.sciencedirect.com/science/article/pii/S0169409X0200090X
The ability to deliver therapeutic agents to a patient in a pulsatile or staggered release profile has been a major goal in drug delivery research over the last two decades. This review will cover methods that have been developed to control drug delivery profiles with implantable polymeric systems.Author: S Sershen, J West
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