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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648939/
Nov 04, 2012 · Oral controlled release systems. Historically, oral drug administration has been the predominant route for drug delivery. It is known to be the most popular route of drug administration due to the fact the gastrointestinal physiology offers more flexibility in dosage form design than most other routes (Chen et al. 2010, Gupta and Robinson 1992, Maderuelo et al. 2011, Tongwen and Binglin 1998).Author: Ali Nokhodchi, Shaista Raja, Pryia Patel, Kofi Asare-Addo
https://www.sciencedirect.com/science/article/pii/S0168365999000966
Configurations of the multifunctional matrix delivery system: case 1, one drug-containing tablet within an impermeable cylinder; case 2, floating device (one tablet at each end of the cylinder with an air-filled space in the middle); case 3, pulsatile system (drug-filled impermeable capsule half closed with an erodible drug-free plug.Author: I Krögel, R Bodmeier
https://www.mddionline.com/polymers-controlled-drug-delivery
Drug delivery from a typical matrix drug delivery system. For the reservoir systems shown in Figures 3a and 3b, the drug delivery rate can remain fairly constant. In this design, a reservoir whether solid drug, dilute solution, or highly concentrated drug solution within a polymer matrix is surrounded by a film or membrane of a rate-controlling ...
https://www.intechopen.com/books/advanced-technology-for-delivering-therapeutics/introductory-chapter-drug-delivery-concepts
However, controlled release systems do not exclusively deliver the drug to the target organ. For this reason, the target-specific drug delivery systems must be designed in order to control biodistribution of the drug. Consequently, various novel concepts have been emerged to meet the specific needs of an ideal drug delivery system.Author: Sabyasachi Maiti, Kalyan Kumar Sen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977044/
Except for the formulation A, which is a matrix tablet and the simplest controlled release drug delivery system composed of the drug and the carrier/retarding polymeric material, all the other devices (based on A) had the two surfaces of the core (top and bottom) covered with Carbopol barriers, thus the formulation consisted of a three-layer ...Author: M. Efentakis, C. Peponaki
https://en.wikipedia.org/wiki/Modified-release_dosage
Matrix systems. The matrix system is the mixture of materials with the drug, which will cause the drug to slow down. However, this system has several subcategories: hydrophobic matrices, lipid matrices, hydrophilic matrices, biodegradable matrices, and mineral matrices. A hydrophobic matrix is a drug mixed with a hydrophobic polymer.
https://www.researchgate.net/post/Matrix_and_reservoir_based_drug_delivery_systems
A matrix system is one where the drug is dispersed in very small particles into a solid and homogeneous block of polymer or release-retardant substance.
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