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https://www.sciencedirect.com/science/article/pii/S2211383515001069
In order to gain marketing exclusivity and patent protection for such products, revitalization of poorly soluble drugs using insoluble drug delivery technologies have been successfully adopted by many pharmaceutical companies. This review covers the recent advances in the field of insoluble drug delivery and business prospects.Author: Sandeep Kalepu, Vijaykumar Nekkanti
https://www.news-medical.net/news/20191004/A-new-delivery-system-for-insoluble-drugs.aspx
Oct 04, 2019 · Researchers have previously used polymers to hold drug compounds in an amorphous state, but drug molecules could still migrate and crystallize in the polymer, which affects solubility and ...
https://www.sciencedirect.com/science/article/pii/S0168365901002760
May 14, 2001 · Biodegradable block copolymers for delivery of proteins and water-insoluble drugs ... thermally reversible drug delivery systems are based on custom designed polymers/processes that control drug release and offer substantial advantages in administration and manufacture. They hold particular promise to provide solutions to the parenteral ...Author: Gaylen M. Zentner, Ramesh Rathi, Chung Shih, James C. McRea, Min Hyo Seo, Hunseung Oh, B. G. Rhee, J...
https://link.springer.com/article/10.1007%2Fs11051-019-4744-6
Jan 04, 2020 · Self-microemulsifying drug delivery system (SMEDDS) is a uniform and transparent solution consisting of oil phase, surfactant, co-surfactant, and a small amount of water. It could be orally administered under gastrointestinal peristalsis and spontaneously dispersed to form an oil-in-water microemulsion with typical particle sizes lower than 100 nm.Author: Beibei Yan, Yingying Ma, Juan Guo, Yancai Wang
https://www.pharmacircle.com/presentations/Water_Insoluble_Strategies.pdf
Water Insoluble Drug Development •Case Studies TriCor/Fenofibrate Kaletra The Inevitable Generic Competition The Emergence of Specialty Pharma Approved Water Insoluble Drugs 2000-2010 •Technology Selection Strategies The Impact of Drug Delivery Life Cycle Management How do you study the space and your competition?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113620/
Apr 02, 2014 · KEY WORDS: anti-cancer drug, drug delivery, nanocarrier, poorly water-soluble drugs, translation INTRODUCTION In the past few decades, many anticancer drug compounds were discovered and developed, most notably the newer chemotherapeutic agents or “chemo-drugs” such as taxanes (e.g. paclitaxel, docetaxel) and platinum-based drugs.Author: Mayuri Narvekar, Hui Yi Xue, June Young Eoh, Ho Lun Wong
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118444726
Jan 21, 2013 · Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials.
https://pubs.acs.org/doi/abs/10.1021/ja803688x
Jul 29, 2008 · It is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In this work, we functionalized nanographene oxide (NGO), a novel graphitic material, with branched polyethylene glycol (PEG) to obtain a biocompatible NGO−PEG conjugate stable in various biological solutions, and used them for attaching hydrophobic aromatic …Author: Zhuang Liu, Joshua T. Robinson, Xiaoming Sun, Hongjie Dai
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597374/
Aug 20, 2008 · PEGylated Nano-Graphene Oxide for Delivery of Water Insoluble Cancer Drugs. Zhuang Liu, Joshua T. Robinson, Xiaoming Sun, and Hongjie Dai * ... The slow but finite release of SN38 in serum was likely caused by the binding of SN38 by serum proteins, 18 useful for drug delivery.Author: Zhuang Liu, Joshua T. Robinson, Xiaoming Sun, Hongjie Dai
https://pubs.acs.org/doi/abs/10.1021/acs.langmuir.6b00214
The selective action of drugs in tumor cells is a major problem in cancer therapy. Most chemotherapy drugs act nonspecifically and damage both cancer and healthy cells causing various side effects. In this study, the preparation of a selective drug delivery system, which is able to act as a carrier for hydrophobic and anticancer drugs is reported.Author: Luciane Franca de Oliveira, Karim Bouchmella, Kaliandra de Almeida Goncalves, Jefferson Bettini, Joe...
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