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https://broomedocs.com/wp-content/uploads/2019/06/Vancomycin-CI-Protocol.pdf#:~:text=When%20using%20a%20continuous%20infusion%20there%20is%20no,the%20first%2024%20hour%20infusion%20bag%20is%20completed.
https://doseme-rx.com/vancomycin/articles/infusion-guidelines
To minimize these adverse reactions, vancomycin should be diluted before it is administered as per the product insert, and infused slowly over a period of at least one hour, or at an infusion rate of 10mg/min or less.
https://health.ucdavis.edu/antibiotic-stewardship/pdfs/vanc_dosing.pdf
Order random vancomycin level within 24 –36 hours of initiation (with AM labs best) a)Repeat QAM until level stays within 10-15% variation from previous b) After any dose adjustment, repeat level within 24 – 48 hours or at estimated steady state
https://www.stonybrookmedicine.edu/sites/default/files/Vanco_Cont_Inf_RPh_Info_080718_0.pdf
Vancomycin continuous infusion must be administered via Central line or Midline . LOADING DOSE If the continuous infusion cannot be started within 4 hours of the last dose of intermittent infusion (please take into consideration of the lag time for pharmacy to deliver the medication), give a loading dose of 20 mg per kg (use actual body weight). Maximum loading dose = 2 gram …
https://broomedocs.com/wp-content/uploads/2019/06/Vancomycin-CI-Protocol.pdf
When using a continuous infusion there is no need to time blood samples to a trough. Vancomycin levels should be taken after “steady-state” is achieved. This occurs at about 24 – 30 hours - approximately at the conclusion of the loading dose + the first 24 hour infusion bag is completed. The level which is collected is a PLATEAU CONCENTRATION.
https://globalrph.com/dilution/vancomycin/
Doses of 15 to 20 mg/kg (based on actual body weight) administered every 8 to 12 hours as an intermittent infusion are recommended for most patients with normal renal function when assuming a MIC BMD of 1 mg/L (A-II). In patients with normal renal function, these doses may not achieve the therapeutic AUC/MIC target when the MIC is 2 mg/L."
https://doseme-rx.com/vancomycin/articles/dosing-guidelines-essentials
For children aged 3 months to less than 12 years, the guidelines recommend 60 to 80mg/kg/day , in divided doses every 6 hours. Recommended dosing for children 12 years and above is 60 to 70mg/kg/day in divided doses given every 6 to 8 hours. Most children should not require more than 3,000 mg/day.
https://accesspharmacy.mhmedical.com/content.aspx?bookid=1374§ionid=74719961
Vancomycin is administered as a short-term (1 hour) intermittent intravenous infusion for doses up to 1500 mg or as a 1.5- to 2-hour intermittent intravenous infusion for larger doses (>1500 mg). Infusion rate–related side effects have been noted when shorter infusion times (∼30 minutes or less) have been used.
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