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https://www.tandfonline.com/doi/abs/10.1517/17460440902751599
Conclusion: Viral-mediated gene delivery is increasingly being used in support of genome scale target validation studies and cell-based assay development for specific drug target genes such as ion channels, G protein-coupled receptors and intracellular enzymes. The choice of a delivery system over another for a particular application is largely dictated by the cell types and cell lines in use, virus cellular tropism, assay throughput, safety requirements …Author: Robert S Ames, Quinn Lu
http://europepmc.org/abstract/MED/23489124
Apr 01, 2009 · CONCLUSION: Viral-mediated gene delivery is increasingly being used in support of genome scale target validation studies and cell-based assay development for specific drug target genes such as ion channels, G protein-coupled receptors and intracellular enzymes.Author: Robert S Ames, Quinn Lu
https://www.researchgate.net/publication/236045122_Ames_RS_and_Lu_Q_Viral-mediated_gene_delivery_for_cell-based_assays_in_drug_discovery_Expert_Opin_Drug_Dis_4_243-256
Conclusion: Viral-mediated gene delivery is increasingly being used in support of genome scale target validation studies and cell-based assay development for specific drug target genes such as ion ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741327/
Jun 01, 2008 · Cell-based assays have also been developed to monitor specific viral proteins in a manner suitable for high-throughput drug screening. Using this approach, a viral gene or promoter is expressed inside a model cell, and the activity of the viral gene/promoter is …Author: Neil Green, Robert D Ott, Richard J Isaacs, Hong Fang
https://www.sciencedirect.com/science/article/pii/S006535270668007X
Examples have been provided here from a wide range of target molecules demonstrating that the ease and versatility of BacMam-mediated gene delivery make it an excellent alternative to stable cell lines for the development of cell-based assays for drug screening.Author: J.Patrick Condreay, Robert S. Ames, Namir J. Hassan, Thomas A. Kost, Raymond V. Merrihew, Danuta E. ...
https://www.researchgate.net/publication/6797565_Baculoviruses_and_Mammalian_Cell-based_Assays_for_Drug_Screening
BacMam technology is based on recombinant baculovirusmediated gene delivery, a system that has widely adopted for cell-based assay development in drug discovery [46][47][48]. Using the FP assay, we compared cellular sEH activities in the various cell lines to that obtained with the sEH BacMam transduced HEK-293 cells.
https://beta-static.fishersci.com/content/dam/fishersci/en_US/documents/programs/scientific/brochures-and-catalogs/publications/promega-selecting-cell-based-assays-drug-screening-publication.pdf
Cell-Based Assays for Drug Discovery CELL-BASED ASSAYS exposure most of the population of cells are in a state of secondary necrosis. Homogeneous Assays for Automated Screening Promega produces a complete portfolio of homogeneous “add-mix-measure” assays that are designed to meet a variety of screening requirements. Some of the assay systems requireFile Size: 282KB
https://link.springer.com/article/10.1208/s12248-019-0403-1
Jan 06, 2020 · Recommendations for the development and validation of cell-based anti-AAV NAb detection methods, including considerations related to selection of appropriate cell line, surrogate vector/reporter gene, assay matrix and controls, and methodologies for calculating assay cut-point are discussed herein.Author: Boris Gorovits, Michele Fiscella, Mike Havert, Eugen Koren, Brian Long, Mark Milton, Shobha Purushot...
https://www.lakepharma.com/services/Bioassays/Cell-Based-Assays
LakePharma performs a wide variety of cell-based assays to support drug discovery efforts in both the small molecule and large molecule arenas. A variety of technologies and platforms are available to support studies at a small scale as well as at a full HTS screen scale.
https://www.sciencedirect.com/science/article/pii/S1359644607001006
Membrane protein targets constitute a key segment of drug discovery portfolios and significant effort has gone into increasing the speed and efficiency of pursuing these targets. However, issues still exist in routine gene expression and stable cell-based assay development for membrane proteins, which are often multimeric or toxic to host cells.Author: Thomas A. Kost, J. Patrick Condreay, Robert S. Ames, Stephen Rees, Michael A. Romanos
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