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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559924/
Jun 25, 2006 · To overcome these barriers several strategies have been developed, such as chemical modifications of siRNA, viral nucleic acid delivery systems, and nonviral nucleic acid delivery systems. Here, we discuss progress that has been made to improve targeted delivery of siRNA in vivo for each of these strategies. INTRODUCTION.Author: Sabrina Oliveira, Gert Storm, Raymond M. Schiffelers
https://www.thermofisher.com/us/en/home/life-science/rnai/delivering-rnai-to-cells-transfection-and-viral-delivery.html.html
Viral delivery can also be used to create stable cell lines with inducible RNAi expression or to express RNAi sequences with tissue-specific promoters. Importance of minimizing transfection-mediated cytotoxicity. The delivery of RNAi reagents, or the delivery method itself, can give rise to cytotoxicity in gene silencing experiments.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · The three goals of this review were to provide an overview of (a) the barriers to siRNA delivery, from the perspectives of physicochemical properties of siRNA, pharmacokinetics and biodistribution, and intracellular trafficking; (b) the non-viral siRNA carriers including cell-penetrating peptides, polymers, dendrimers, siRNA bioconjugates, and ...Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.alliedacademies.org/articles/rethinking-delivery-viral-vectors-and-rna-interference-7646.html
These shRNAs are processed by the cellular machinery into siRNAs, which then knockdown the target gene. This strategy not only allows prolonged silencing, as the shRNAs are continuously produced, it also opens up the possibility of using viral vectors for the delivery of double-stranded RNA molecules.Author: Jens Kurreck
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/enhanced-sirna-delivery-and-long-term-gene-silencing.html
In contrast, viral approaches facilitate effective siRNA delivery into many difficult-to-transfect cell types, including primary cells, because infection is a much more efficient delivery mechanism than transfection.
https://www.intechopen.com/books/rna-interference/non-viral-sirna-and-shrna-delivery-systems-in-cancer-therapy
Development of appropriate delivery systems is an important issue in the use of siRNA-based therapeutics. Non-viral delivery systems have great potential for safe and effective delivery of siRNA therapeutics to tumor cells. Nanocarriers such as nanoplexes, lipoplexes, nanoparticles, and liposomes have been commonly used for siRNA delivery.Author: Emine Şalva, Ceyda Ekentok, Suna Özbaş Turan, Jülide Akbuğa
https://www.sciencedirect.com/science/article/pii/S1818087614000646
If siRNA delivery provokes unacceptable toxicity on either a cellular or systemic level, even the most efficacious siRNA delivery system will be rendered useless. Viral vectors, which were among the first vehicles to be studied for siRNA delivery, can induce unacceptable levels of toxicity through the activation of immune responses [38] .Author: Cong-fei Xu, Jun Wang
https://www.sciencedirect.com/science/article/pii/S0169409X09000969
Non-viral polymeric delivery systems, in particular those with biodegradable components, have much better safety profiles than their viral counterparts though their transfection efficiency is generally lower , , . Non-viral vehicles for delivery of siRNA and shRNA are typically cationic preparations.Author: Donald D. Rao, John S. Vorhies, Neil Senzer, John Nemunaitis
https://www.nature.com/articles/gt20175
Jan 17, 2017 · Because of its safe and effective protein expression profile, in vitro transcribed messenger RNA (IVT-mRNA) represents a promising candidate in the development of …Author: S Guan, J Rosenecker
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · Therapeutics based on small interfering RNA (siRNA), which in principle are able to reversibly silence any gene of interest, are under development for the …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
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