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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841970/
Patients with completely resected stage IB-III NSCLCs were treated with up to 4 cycles of docetaxel and vinorelbine at the recommended phase II dose. The primary endpoint was drug delivery compared to historical delivery of adjuvant cisplatin plus vinorelbine. Secondary endpoints were toxicity and feasibility.Author: Jamie E. Chaft, Jamie E. Chaft, Natasha Rekhtman, Camelia S. Sima, Valerie Rusch, Mark G. Kris, Mark...
https://www.sciencedirect.com/science/article/pii/S0168365913003982
Polymeric micelles have been proven to be a promising nano-sized system for drug delivery. Understanding its in vivo behaviors at the whole body, tissue and cellular levels is critical for translating this drug delivery system into clinical practice. In this study, the 14.5 nm micelles made of polyethylene glycol-phosphatidylethanolamine (PEG-PE) for delivery of doxorubicin and vinorelbine ...Author: Lei Qin, Fayun Zhang, Xiaoyan Lu, Xiuli Wei, Jing Wang, Xiaocui Fang, Duanyun Si, Yiguang Wang, Chun...
https://www.ncbi.nlm.nih.gov/pubmed/31371950
Jul 11, 2019 · In addition, the dual drug-loaded liposomes instigated significant reduction in lung metastasis in those experiments. Conclusion: Taken together, this study demonstrates that co-delivery of everolimus and vinorelbine with a tumor-targeted liposomal formulation is an effective approach to achieve improved therapeutic outcome in RCC. PMCID ...Author: Krishnendu Pal, Vijay Sagar Madamsetty, Shamit Kumar Dutta, Debabrata Mukhopadhyay
https://www.drugs.com/history/exelbine.html
Oct 03, 2011 · Exelbine (formerly ANX-530) is a proprietary emulsion formulation of vinorelbine intended to reduce the incidence and severity of vein irritation associated with intravenous delivery of the drug. Exelbine is intended for the treatment of non-small cell lung cancer.
https://www.dovepress.com/co-delivery-of-everolimus-and-vinorelbine-via-a-tumor-targeted-liposom-peer-reviewed-fulltext-article-IJN
Drug-loaded liposomes were prepared as described earlier. A schematic representation has been displayed in Figure 1A. The hydrophilic drug vinorelbine was added to the aqueous phase, while the lipophilic drug everolimus was added to the ethanolic solution of lipids. Both single drug and combined drug-loaded liposomes were prepared.Author: Krishnendu Pal, Vijay Sagar Madamsetty, Shamit Kumar Dutta, Debabrata Mukhopadhyay
https://link.springer.com/article/10.1007/s11095-016-2012-3
Aug 19, 2016 · To evaluate vinorelbine drug exposure and activity in brain metastases of the human MDA-MB-231BR breast cancer model using integrated imaging and analysis. Brain and systemic metastases were created by administration of cancer cells in female NuNu mice. After metastases developed, animals were administered vinorelbine at the maximal tolerated dose (12 mg/kg), and …Author: Ramakrishna Samala, Helen R. Thorsheim, Satyanarayana Goda, Kunal Taskar, Kunal Taskar, Brunilde Gri...
https://www.tandfonline.com/doi/pdf/10.3109/10717541003702769
Polymeric micelles as a drug delivery system enhance cytotoxicity of vinorelbine 257 Bid, Bax, β-actin (Santa Cruz Biotechnology), cyclin B1, p-Cdc2 (Tyr15), and p-Cdc2 (Thr161) (Cell Signal).After that, the membranes were washed and probed with a
https://www.sciencedirect.com/science/article/abs/pii/S0022354916317737
Vinorelbine (VRL) is a particularly lipophilic member of the vinca alkaloids which, as a class of drugs, exhibit improved cytotoxicity and therapeutic activity through increased duration of exposure.Author: Sean C. Semple, Robert Leone, Jinfang Wang, Esther C. Leng, Sandra K. Klimuk, Merete L. Eisenhardt, ...
https://www.nejm.org/doi/full/10.1056/NEJMoa043623
Data concerning drug delivery, treatment compliance, and quality of life were reported previously. 15,16 At least one dose of medication was received by 231 patients (95.5 percent); 11 of the ...Author: Timothy Winton, Robert B Livingston, David Johnson, James Rigas, Michael Johnston, Charles Butts, Yv...
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