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https://www.sciencedirect.com/science/article/pii/S0939641100001107
1. Introduction. Calcium-induced alginate gel beads (Alg–Ca) have been developed in recent years as a unique vehicle for drug delivery. Alg–Ca is rapidly formed by gelation of alginic acid in the presence of calcium ions and is able to incorporate some compounds such as drugs or polysaccharides in the gel matrix , .The beads have been used in various ways in the gastrointestinal tract, for ...Author: Y Murata, N Sasaki, E Miyamoto, S Kawashima
https://www.sciencedirect.com/science/article/abs/pii/S0939641100001107
The second, alginate gel bead containing chitosan (ALCS), is a dried gel bead with dispersed chitosan in the matrix. The drug-release profile was not affected by the kind of chitosan contained in ALCS. When ALCS containing MZ was administered orally to guinea pigs, it floated on the gastric juice and released the drug into the stomach.Author: Y Murata, N Sasaki, E Miyamoto, S Kawashima
https://www.ncbi.nlm.nih.gov/pubmed/10962231
Use of floating alginate gel beads for stomach-specific drug delivery. Murata Y(1), Sasaki N, Miyamoto E, Kawashima S. Author information: (1)Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan. [email protected] Two types of alginate gel beads capable of floating in the gastric cavity were prepared.Author: Y Murata, N Sasaki, E Miyamoto, S Kawashima
https://www.researchgate.net/publication/12360250_Use_of_floating_alginate_gel_beads_for_stomach-specific_drug_delivery
Use of floating alginate gel beads for stomach-specific drug delivery Article in European Journal of Pharmaceutics and Biopharmaceutics 50(2):221-6 · October …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750363/
Murata Y, Sasaki N, Miyamoto E, Kawashima S. Use of floating alginate beads for stomach-specific drug delivery. Eur J Pharm Biopharm. 2000; 50 :221–226. doi: 10.1016/S0939-6411(00)00110-7.Author: Shishu, Neeta Gupta, Nidhi Aggarwal
http://ijpsnonline.com/Issues/1092_full.pdf
1092 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 3 • Issue 3 • October-December 2010 Research Paper Floating In Situ Gel based on Alginate as Carrier for Stomach-Specific Drug Delivery of Famotidine Jayvadan K. Patel1, Jayant R. Chavda2 and Moin K. Modasiya3 1Nootan Pharmacy College, Visnagar, India. 2 B.K.Modi Government Pharmacy College, Rajkot, India.
https://www.researchgate.net/publication/10628344_Preparation_of_floating_alginate_gel_beads_for_drug_delivery_to_the_gastric_mucosa
(9,10) Such beads have also been used in the design of floating systems in order to prolong gastric retention time (11,12) The floating and sustained drug release properties of calcium alginate ...
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