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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664547/
Nov 23, 2015 · The bladder is an ideal target for local drug delivery as it is easily accessed through the urethra. IDD is however hindered by continuous filling of the bladder with urine, the low permeability of the BPB, and the washout during voiding. Hence, serial drug instillations are often required.Author: Martino Maria Zacchè, Sushma Srikrishna, Linda Cardozo
https://quizlet.com/236443686/vaginal-and-urethral-drug-delivery-flash-cards/
transurethral drug delivery for erectile dysfunstion prostaglandin E1; relax muscles and widen blood vessels in the penis PEG-based microsuppository 1.4 mm (0.05 inch) (diameter), 3 or 6 mm long fast …
An exciting, minimally invasive urethral stricture treatment, the Optilume drug-coated balloon was developed in response to severe patient and physician dissatisfaction with current stricture solutions. This proprietary technology combines balloon dilation and drug delivery, and is well-tolerated by patients.
http://www.eurekaselect.com/114722/article
The transmucosal route includes oral, nasal, vaginal, and urethral and presents a challenge in the field of novel drug delivery technology. The oral transmucosal delivery, especially the buccal and sublingual routes have been explored successfully for a number of drugs in the last few decades with novel approaches emerging continuously.Author: Pooja Abhang, Munira Momin, Mayur Inamdar, Swapan Kar
https://www.technicaljournalsonline.com/ijpsr/VOL%20I/IJPSR%20VOL%20I%20ISSUE%20I%20JULY%20SEPTEMBER%202010/IJPSR%20VOL%20I%20ISSUE%20I%20Article%208.pdf
This route is called urethral route of drug administration.(10) Advantages:- Advantages of rectal/urethral/vaginal route are as follows:- 1. Unconscious patients and children:- If the patient is unconscious then it is not possible to give the drug orally. So in this situation the drug can be given through rectal/urethral/vaginal route. 2.
https://www.urologicalcare.com/erectile-dysfunction/urethral-medications-for-ed/
The urethral medication (alprostadil) comes in a plastic applicator, is prefilled and ready to use. The physician determines the proper dose. One must insert the prefilled applicator 1.25" into the opening of the penis. A pellet of alprostadil is then pushed out of the applicator into the canal where urine travels.
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