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https://www.sciencedirect.com/science/article/pii/S0168365911009473
Non-viral gene delivery is currently a hot subject for its relative safety and simplicity of use; however, it is still far from being ideal enough to be clinically used for its comparatively lower efficiency than viral gene delivery. To improve the efficiency of non-viral gene delivery needs a comprehensive understanding of the uptake mechanisms.Author: Shengnan Xiang, Haijun Tong, Haijun Tong, Qin Shi, Julio C. Fernandes, Tuo Jin, Kerong Dai, Xiaoling...
https://www.sciencedirect.com/science/article/abs/pii/S0168365911009473
Non-viral gene delivery is currently a hot subject for its relative safety and simplicity of use; however, it is still far from being ideal enough to be clinically used for its comparatively lower efficiency than viral gene delivery. To improve the efficiency of non-viral gene delivery needs a comprehensive understanding of the uptake mechanisms.
https://www.ncbi.nlm.nih.gov/pubmed/21982904
Mar 28, 2012 · Non-viral gene delivery is currently a hot subject for its relative safety and simplicity of use; however, it is still far from being ideal enough to be clinically used for its comparatively lower efficiency than viral gene delivery. To improve the efficiency of non-viral gene delivery needs a comprehensive understanding of the uptake mechanisms.Author: Shengnan Xiang, Haijun Tong, Haijun Tong, Qin Shi, Julio C. Fernandes, Tuo Jin, Kerong Dai, Xiaoling...
https://www.researchgate.net/publication/51702494_Uptake_mechanisms_of_non-viral_gene_delivery
To improve the efficiency of non-viral gene delivery needs a comprehensive understanding of the uptake mechanisms. Macromolecules are internalized into cells by a variety of mechanisms, and their ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782077/
Oct 16, 2009 · EXTRA- AND INTRACELLULAR BARRIERS FOR GENE DELIVERY. Several anatomical and cellular barriers limit the overall efficiency of gene transfer by nonviral methods (Fig. 1).Anatomical barriers are epithelial, endothelial cell linings and the extracellular matrix surrounding the cells that prevent direct access of macromolecules to the target cells.Author: Mohammed S. Al-Dosari, Xiang Gao
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Similar to the mechanism of non-viral vector-based gene delivery, the cellular uptake of DNA is due to endocytosis and pinocytosis . This method has been successfully applied to a wide range of primary cells, and cells that are difficult to transfect by other non-viral vectors [ 137 ].Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://link.springer.com/article/10.1007/s11095-010-0364-7
Jan 12, 2011 · Indeed, the size of these materials has been shown to result in interesting biological properties, some of which have been successfully applied to gene-delivery processes. The efficiency of the uptake process using non-viral gene-delivery agents depends on the cell type, the target site and the specific carrier composition.Author: Francisco C. Pérez-Martínez, Javier Guerra, Inmaculada Posadas, Inmaculada Posadas, Valentín Ceña, V...
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