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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676802/
Ultrasound enhanced transdermal drug delivery offers advantages over traditional injection drug delivery methods which are invasive and painful. Currently few drugs, proteins or peptides have been successfully administered transdermally for clinical applications because of the low skin permeability to these relatively large molecules.Author: Nadine Barrie Smith
https://stm.sciencemag.org/content/7/310/310ra168.full
Oct 21, 2015 · Ultrasound-mediated drug delivery could be used for other drugs, such as hydrocortisone, and even macromolecules, such as insulin, as demonstrated by the authors, thus serving as a simple physical solution to the barrier challenge in gastrointestinal drug delivery.Author: Carl M. Schoellhammer, Avi Schroeder, Avi Schroeder, Ruby Maa, Gregory Yves Lauwers, Albert Swiston,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026001/
Ultrasound-mediated drug delivery for cardiovascular disease Jonathan T Sutton , BS, 1 Kevin J Haworth , PhD, 2, 1 Gail Pyne-Geithman , DPhil, 3, 4 and Christy K Holland , PhD 1, 2, † 1 University of Cincinnati, College of Engineering and Applied Science, …Author: Jonathan T Sutton, Kevin J Haworth, Gail Pyne-Geithman, Christy K Holland
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825174/
Oct 21, 2015 · The purpose of this study was to investigate the safety, tolerability, and utility of ultrasound-mediated drug delivery in the GI tract in tissue ex vivo as well as in vivo in Yorkshire pigs and mice. Low-frequency (<100 kHz) ultrasound was used and administered directly to GI tissue.Author: Carl M. Schoellhammer, Avi Schroeder, Avi Schroeder, Ruby Maa, Gregory Yves Lauwers, Albert Swiston,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702264/
Focused ultrasound (FUS) is one method to transiently increase permeability of the BBB to promote drug delivery to specific brain regions. An introduction to the BBB and a brief overview of the methods which can be used to circumvent the BBB to promote drug delivery is provided.Author: Alison Burgess, Kairavi Shah, Olivia Hough, Kullervo Hynynen
https://www.sciencedirect.com/science/article/pii/S0168365914007342
While ultrasound is a well-established diagnostic imaging technique, its great potential in enhancing drug delivery was only acknowledged in the late 1990s . Since then, the ultrasound mediated uptake of small drugs , proteins , as well as larger nanoparticles such as gene complexes or drug loaded liposomes has been reported. In these studies, ultrasound is often used in combination with …Author: Ine De Cock, Elisa Zagato, Kevin Braeckmans, Ying Luan, Nico de Jong, Stefaan C. De Smedt, Ine Lenta...
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30332-2/fulltext
The combined treatment of LTLD and non-invasive focused ultrasound hyperthermia in this study seemed to be clinically feasible, safe, and able to enhance intratumoural drug delivery, providing targeted chemo-ablative response in human liver tumours that were refractory to standard chemotherapy.
http://tcr.amegroups.com/article/view/3354/html
Ultrasonic drug delivery has been limited to in vitro experiments for decades. Promising in vivo results have accumulated in the past ten years and this field is now nearing clinical trials. Ultimately, FUS-enhanced drug delivery is one tool in the armamentarium for optimal treatment of cancer.
http://www.thno.org/v04p1133.htm
Ultrasound-Mediated Gene and Drug Delivery Using a Microbubble-Liposome Particle System Young Il Yoon 1,2,3 *, Yong-Su Kwon 4 *, Hee-Sang Cho 4 , Sun-Hee Heo 5 , Kyeong Soon Park 5 , Sang Gyu Park 5 , Soo-Hong Lee 5 , Seung Il Hwang 1,2 , Young Il Kim 1 , Hwan Jun Jae 1 , Gook-Jun Ahn 7 , Young-Seok Cho 8 , Hakho Lee 9 , Hak Jong Lee 1,2,3,10 ...
https://www.researchgate.net/publication/286053692_Capsule-based_Ultrasound-mediated_Targeted_Gastrointestinal_Drug_Delivery
Ultrasound-mediated delivery facilitated by microbubbles provides a novel means for intracellular drug and gene delivery and particularly a noninvasive strategy uniquely suitable for clinical ...
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