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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322956/
Dysfunctional Tregs are required for adverse LV remodeling at the tissue and chamber level, with prominent pathological effects on hypertrophy, fibrosis, and tissue neovascularization, the last related to both TNFR1-dependent direct effects on ECs and Treg-mediated regulation, in part through CCL5/CCR5, of CAC mobilization and recruitment. ...
https://pubmed.ncbi.nlm.nih.gov/31353330/
Regulatory T cells (Tregs) are responsible for immune tolerance and are usually activated in secondary lymphatic tissues. Activated Tregs subsequentl … Inflammation and immune responses after tissue injury play pivotal roles in the resolution of inflammation, tissue recovery, fibrosis, and remodeling.
https://pubmed.ncbi.nlm.nih.gov/29898397/
Disruption of EZH2 activity in Tregs, either pharmacologically or genetically, drove the acquisition of pro-inflammatory functions in TI-Tregs, remodeling the tumor microenvironment and enhancing the recruitment and function of CD8 + and CD4 + effector T cells that eliminate tumors. Moreover, abolishing EZH2 function in Tregs was ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861083/
The left anterior descending coronary artery was occluded for 1 hour then reperfused for 6 hours to 7 days. At the end of the experiment, the chest was opened and the heart was immediately excised, fixed in zinc-formalin, and embedded in paraffin for histological studies, or snap frozen and stored at −80°C for RNA isolation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525592/
In addition, since the in vitro coculture lasted 72 hours with no replenishment of additional IL-35, and the vital Treg ratios in the collection time were obviously lower than those in the initial mixtures, Treg stability and the cell death in vitro may affect the in vitro Treg-suppression results . Hence, further assays beyond simply measuring the suppression of Teff …
https://medicaltrend.org/2021/07/15/immune-related-adverse-reactions-caused-by-immunotherapy/
These abnormally up-regulated features are on Tregs in other autoimmune diseases. There are also manifestations, indicating that inflammatory Tregs remodeling is a feature of irAEs induced by immunotherapy. Image source: Cancer Immunol. Res. Main research contents. Transcriptome reprogramming of peripheral blood Tregs in patients with irAEs
https://pubmed.ncbi.nlm.nih.gov/29688896/
Mechanistically, Nox2-/y Tregs showed higher in vitro suppression of Teff proliferation than WT Tregs, increased nuclear levels of FoxP3 and NF-κB, and enhanced transcription of CD25, CD39, and CD73. Adoptive transfer of Tregs confirmed that Nox2-deficient cells had greater inhibitory effects on Ang II-induced heart remodeling than WT cells.
https://www.sciencedirect.com/science/article/pii/S221112472101384X
Tregs have been found to use fatty acids for OXPHOS and promote lipid storage (Howie et al., 2017; Howie et al., 2019; Michalek et al., 2011), but it is interesting to note that inhibiting mitochondrial enzymes such as FABP5, resulting in loss of mitochondrial cristae structure and metabolism, promotes Treg suppressive activity (Field et al ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367765/
Together, these findings identify key pro-resolving functions, licensed by Tregs in regressing plaques that are essential for plaque remodeling and contraction, and support that therapeutic expansion of Tregs, in conjunction with lipid lowering, may hold promise for the treatment of atherosclerotic inflammation and reversal of plaque burden.
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