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https://www.ncbi.nlm.nih.gov/pubmed/22888629
[Types of non-viral delivery systems of small interfering RNA]. Glebova KV, Marakhonov AV, Baranova AV, Skoblov MIu. To date, RNA interference remains the most powerful and promising tool for gene-targeted therapy. Several problems still have to be solved for its successful use in clinics.Author: Glebova Kv, Marakhonov Av, Baranova Av, Skoblov MIu
https://en.wikipedia.org/wiki/Small_interfering_RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA non-coding RNA molecules, 20-25 base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692493/
Jun 01, 2009 · Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res. 2005; 65:8984–8992.Author: Kun Gao, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S0022354915308790
Despite these differences, similar delivery criteria exist between the two nucleic acid cargoes and so many of the non-viral vectors which were originally developed for pDNA are, more recently, being applied to delivery of siRNA. 15 Traditional non-viral delivery systems are based on electrostatic interactions of cationic molecules with negatively charged nucleic acids [e.g., cationic lipids,16., 17. polymers…Author: Aoife M. O’Mahony, Bruno M.D.C. Godinho, John F. Cryan, Caitriona M. O’Driscoll
http://geneticeducation.co.in/sirna-small-interfering-rna-structure-and-function/
The siRNA also known as small interfering ribonucleic acid or silencing RNA is a molecule prevents the gene expression. The entire process of gene silencing through the siRNA is called a mechanism of RNA interference or siRNA knockdown. The siRNA is functionally and structurally different from the other type of RNAs.
https://www.ncbi.nlm.nih.gov/pubmed/17694447
Nonviral in vivo delivery of therapeutic small interfering RNAs. Aigner A(1). Author information: (1)Philipps-University Marburg School of Medicine, Department of Pharmacology and Toxicology, Karl-von-Frisch-Strasse 1, D-35033 Marburg, Germany. [email protected]: Aigner A
http://ijpsr.com/bft-article/review-on-non-viral-delivery-systems-for-sirna/?view=fulltext
The siRNA delivery system selection is based on target cell type. The siRNA delivery systems are categorized as viral and non-viral delivery systems. Non-viral delivery system includes liposomes; polymers; peptides etc. are the widely studied delivery systems for siRNA. Non-viral delivery systems have advantages of control over functionality ...
https://www.researchgate.net/publication/253335554_Non-Viral_Nanosystems_for_Gene_and_Small_Interfering_RNA_Delivery_to_the_Central_Nervous_System_Formulating_the_Solution
There are challenges to gene and siRNA (small interfering RNA) delivery which are specific to the CNS, including the post-mitotic nature of neurons, their resistance to transfection and the...
https://www.nature.com/articles/nature05901
Jun 17, 2007 · Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain. This 29-amino-acid peptide specifically binds to the acetylcholine receptor expressed by neuronal cells.Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://www.researchgate.net/publication/274315448_REVIEW_ON_NON-VIRAL_DELIVERY_SYSTEMS_FOR_siRNA
The siRNA delivery systems are categorized as viral and non-viral delivery systems. Non-viral delivery system includes liposomes; polymers; peptides etc. are the widely studied delivery systems ...
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