Tumor Targeted Gene Delivery

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Tumor Regression by Targeted Gene Delivery to the ...

    https://science.sciencemag.org/content/296/5577/2404.full
    Jun 28, 2002 · In summary, we have shown that pronounced tumor regressions can be achieved in mice by systemic delivery of an antiangiogenic gene that is targeted to the tumor vasculature. Several components of...Author: John D. Hood, Mark Bednarski, Ricardo Frausto, Samira Guccione, Ralph A. Reisfeld, Rong Xiang, David...

Systemic Tumor-targeted Gene Delivery by Anti-Transferrin ...

    https://mct.aacrjournals.org/content/1/5/337
    Mar 01, 2002 · This new approach provides a promising system for tumor-targeted gene delivery that may have potential for systemic gene therapy of various human cancers. An ideal therapeutic for cancer would be one that selectively targets to tumor cells, is nontoxic to normal cells, and that could be systemically delivered, thereby reaching metastases as well as primary tumor.Author: Liang Xu, Cheng-Cheng Huang, Weiqun Huang, Wen-Hua Tang, Antonina Rait, Yu Zhi Yin, Idalia Cruz, Lai...

Tumor regression by targeted gene delivery to the ...

    https://www.ncbi.nlm.nih.gov/pubmed/12089446
    Jun 28, 2002 · Here we show that a cationic nanoparticle (NP) coupled to an integrin alphavbeta3-targeting ligand can deliver genes selectively to angiogenic blood vessels in tumor-bearing mice. The therapeutic efficacy of this approach was tested by generating NPs conjugated to a mutant Raf gene, ATPmu-Raf, which blocks endothelial signaling and angiogenesis in response to multiple growth factors.Author: John D. Hood, Mark Bednarski, Ricardo Frausto, Samira Guccione, Ralph A. Reisfeld, Rong Xiang, David...

Receptor-mediated, tumor-targeted gene delivery using ...

    https://www.ncbi.nlm.nih.gov/pubmed/22482910
    May 07, 2012 · Receptor-mediated, tumor-targeted gene delivery using folate-terminated polyrotaxanes. Zhou Y(1), Wang H, Wang C, Li Y, Lu W, Chen S, Luo J, Jiang Y, Chen J. Author information: (1)Department of Pharmaceutical Science, Nanfang Hospital, …Author: Yi Zhou, He Wang, Chengxi Wang, Yueshan Li, Wenfeng Lu, Shuifang Chen, Jiandong Luo, Yongnan Jiang, ...

(PDF) Tumor-targeted gene delivery: an attractive strategy ...

    https://www.researchgate.net/publication/11339247_Tumor-targeted_gene_delivery_an_attractive_strategy_to_use_highly_active_effector_molecules_in_cancer_treatment
    based gene delivery systems which are able to target gene expression to distant tumors after systemic application. Tumor-specific targeting is achieved by …

Efficient targeted tumor imaging and secreted endostatin ...

    https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-0712-8
    Mar 02, 2018 · Furthermore, targeted CD105 therapy has minimal delivery barriers, and the destruction of only a small number of tumor ECs can potentially lead to the death of many tumor cells . Overall, CD105 is an attractive target for molecular imaging and cancer therapy.Author: Huiqin Zhuo, Baoshi Zheng, Jianming Liu, Yong Huang, Huiling Wang, Duo Zheng, Naiquan Mao, Jinyu Men...

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