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https://www.sciencedirect.com/science/article/pii/0169409X9390016W
(b) Water-insoluble mucoadhesive polymer; the polymer remains atthched to the mucus until the mucus is replaced or until the shear forces of blinking dislodge the system. OPHTHALMIC MUCOADHESIVE DRUG DELIVERY SYSTEMS 353 front of the eye and attach to the mucin coating.Author: Jane L. Greaves, Clive G. Wilson
https://www.sciencedirect.com/science/article/abs/pii/0169409X9390016W
Treatment of diseases of the eye with mucoadhesive delivery systems. ... Delivery of drugs to the eye is complicated by the efficient removal mechanisms in the precorneal area which serve to maintain a good refractive surface. The absorption of drugs into the eye requires a prolonged precorneal residence time and good corneal permeation ...Author: Jane L. Greaves, Clive G. Wilson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053525/
This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255397/
Mucoadhesive drug delivery systems have applications from different angles, including development of novel mucoadhesives, design of the device, mechanisms of mucoadhesion and permeation enhancement. With the influx of a large number of new drug molecules due to drug discovery, mucoadhesive drug delivery will play an even more important role in ...
https://www.naturaleyecare.com/shop/hylatears-lubricant-eye-drops.html
Saettone MF, Monti D, Torracca MT, Chetoni P. Mucoadhesive ophthalmic vehicles: evaluation of polymeric low-viscosity formulations. J Ocul Pharmacol. 1994;10:83–92. Greaves JL, Wilson CG. Treatment of diseases of the eye with mucoadhesive delivery systems. Adv Drug Delivery Rev. 1993;11:349–383.
https://www.researchgate.net/publication/232010943_Drug_Delivery_from_the_Oral_Cavity_A_Focus_on_Mucoadhesive_Buccal_Drug_Delivery_Systems
For the treatment of chronic diseases, the mucoadhesive buccal drug delivery system allows easily accessibility and is generally well-accepted for administeringdrugs by systemic action. Discover ...
http://www.scielo.br/pdf/bjps/v46n1/02.pdf
Mucoadhesive drug delivery systems 3 the contact between the mucoadhesive and the mucous membrane, with spreading and swelling of the formu-lation, initiating its deep contact with the mucus layer (Hägerstrom, 2003). In some cases, such as for ocular or vaginal formulations, the delivery system is mechanically attached over the membrane.
https://www.researchgate.net/publication/269695968_Mucoadhesive_Polymers_for_Enhancing_Retention_in_Ocular_Drug_Delivery_A_Critical_Review
Mucoadhesive Polymers for Enhancing Retention in Ocular Drug Delivery: A Critical Review ... of mucoadhesive drug delivery systems include the prolongation of residence . ... severe eye diseases ...
https://www.liebertpub.com/doi/abs/10.1089/jop.1986.2.67
The design of ocular drug delivery systems is undergoing a gradual transition from an empirical to a rational base. This is partly due to a better understanding of the constraints on drug disposition in the eye and partly due to improved approaches in animal and clinical assessment of ocular drugs and drug delivery systems.Author: Vincent H.L. Lee, Joseph R. Robinson
https://en.wikipedia.org/wiki/Mucoadhesion
Mucoadhesion describes the attractive forces between a biological material and mucus or mucous membrane. Mucous membranes adhere to epithelial surfaces such as the gastrointestinal tract (GI-tract), the vagina, the lung, the eye, etc. They are generally hydrophilic as they contain many hydrogen macromolecules due to the large amount of water (approximately 95%) within its composition.
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