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https://www.ncbi.nlm.nih.gov/pubmed/10680979
The purpose of this research is to clarify the feasibility and to determine the extent of transnasal drug delivery to the brain through the cerebrospinal fluid (CSF) in the rat…Author: Toshiyasu Sakane, Shinji Yamashita, Noboru Yata, Hitoshi Sezaki
https://www.ncbi.nlm.nih.gov/pubmed/19446619
Jul 30, 2009 · The transnasal delivery of 5-fluorouracil to the rat brain is enhanced by acetazolamide (the inhibitor of the secretion of cerebrospinal fluid). Shingaki T(1), Hidalgo IJ, Furubayashi T, Katsumi H, Sakane T, Yamamoto A, Yamashita S. Author information: (1)Absorption Systems, 440 Creamery Way, Suite 300, Exton, PA 19341, USA. TShingaki ...Author: Tomotaka Shingaki, Ismael J. Hidalgo, Tomoyuki Furubayashi, Hidemasa Katsumi, Toshiyasu Sakane, Akir...
https://www.tandfonline.com/doi/abs/10.3109/10611869909085506
Feb 24, 2014 · The purpose of this research is to clarify the feasibility and to determine the extent of transnasal drug delivery to the brain through the cerebrospinal fluid (CSF) in the rat, using 3 H-5-fluorouracil (5FU) as a model drug. It was confirmed first that the concentration of 5FU in the CSF was significantly higher following nasal administration compared with intravenous injection, indicating ...Author: Toshiyasu Sakane, Shinji Yamashita, Noboru Yata, Hitoshi Sezaki
https://www.sciencedirect.com/science/article/pii/S0378517309002956
Jul 30, 2009 · The purpose of the research is to evaluate the effect of acetazolamide (AZA), an inhibitor of the secretion of cerebrospinal fluid (CSF), on the direct drug transport from the nasal cavity to the CSF and the brain uptake of a model drug, 5-fluorouracil (5FU). 5FU was infused intravenously or perfused nasally in the presence and absence of intravenously administered AZA.Author: Tomotaka Shingaki, Ismael J. Hidalgo, Tomoyuki Furubayashi, Hidemasa Katsumi, Toshiyasu Sakane, Akir...
https://www.researchgate.net/publication/24431553_The_transnasal_delivery_of_5-fluorouracil_to_the_rat_brain_is_enhanced_by_acetazolamide_the_inhibitor_of_the_secretion_of_cerebrospinal_fluid
The purpose of this research is to clarify the feasibility and to determine the extent of transnasal drug delivery to the brain through the cerebrospinal fluid (CSF) in the rat, using 3H-5 ...
https://www.hindawi.com/journals/ecam/2015/729679/ref/
Herb-Drug Pharmacokinetic Interaction of a Traditional Chinese Medicine Jia-Wei-Xiao-Yao-San with 5-Fluorouracil in the Blood and Brain of Rat Using Microdialysis ... and H. Sezaki, “Transnasal delivery of 5-fluorouracil to the brain in the rat ... in Taiwan during 2002,” Evidence-Based Complementary and Alternative Medicine, vol. 2011 ...Author: Meng-Hsuan Chiang, Li-Wen Chang, Ju-Wen Wang, Lie-Chwen Lin, Tung-Hu Tsai
https://www.researchgate.net/publication/45581922_Transnasal_Delivery_of_Methotrexate_to_Brain_Tumors_in_Rats_A_New_Strategy_for_Brain_Tumor_Chemotherapy
Transnasal drug delivery has been tested in animals for various treatments, including methotrexate or 5-FU (5-fluorouracil) [160][161] [162]. However, it has not been used in humans to treat brain ...
http://onlinelibrary.wiley.com/doi/10.1111/j.2042-7158.1994.tb03817.x/abstract
Apr 12, 2011 · 14 Tomotaka Shingaki, Ismael J. Hidalgo, Tomoyuki Furubayashi, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto, Shinji Yamashita, The transnasal delivery of 5-fluorouracil to the rat brain is enhanced by acetazolamide (the inhibitor of the secretion of cerebrospinal fluid), International Journal of Pharmaceutics, 2009, 377, 1-2, 85CrossRef
https://www.sciencedirect.com/science/article/pii/S1347436715305796
Nasal Delivery of P-gp Substrates to the Brain through the Nose–Brain Pathway ... T. Furubayashi, H. Katsumi, T. Sakane, A. Yamamoto, S. Yamashita, The transnasal delivery of 5-fluorouracil to the rat brain is enhanced by acetazolamide (the inhibitor of the secretion of cerebrospinal fluid) Int. J. Pharm. 377: (2009) 85-91 34) T. Obradovic, G ...Author: Tomotaka Shingaki, Ismael J. Hidalgo, Tomoyuki Furubayashi, Toshiyasu Sakane, Hidemasa Katsumi, Akir...
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-017-0277-2
Jun 02, 2017 · The diagrammatic sketch of “Nasal delivery of nanoliposome-encapsulated ferric ammonium citrate can increase the iron content of rat brain”. Nanoliposome-encapsulated ferric ammonium citrate (FAC-LIP) was successfully prepared and intranasal administration of FAC-LIP increased both the total iron contents and iron storage protein (FTL) expression in rat olfactory bulb, …Author: Xueling Guo, Hong Zheng, Yuetong Guo, Yan Wang, Gregory J. Anderson, Yunzhe Ci, Peng Yu, Lina Geng, ...
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