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https://www.sciencedirect.com/science/article/pii/S0142961200000119
The low bioavailabilities in those that had been tested in vivo demonstrate the difficulty in designing successful delivery systems. Yet, the studies presented here offer a good nucleus of biomaterial-based devices that could be improved for better transmucosal delivery of calcitonin.Author: Madeline Torres-Lugo, Nikolaos A Peppas
https://www.researchgate.net/publication/12507142_Transmucosal_delivery_systems_for_calcitonin_A_review
However, promising novel oral delivery systems have been developed. 5-CNAC, formulated with the peptide salmon calcitonin, is in phase III clinical trials for the treatment of osteoporosis or ...
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.384.1224
Researchers have studied di!erent routes to deliver salmon calcitonin more e!ectively, including nasal, oral, vaginal and rectal delivery. These systems are designed to protect the polypeptide from the biological barriers that each delivery route imposes. Oil-based and polymer-based delivery systems are
https://www.sciencedirect.com/science/article/pii/S0168365911000332
Another factor of the buccal epithelium that can affect the mucoadhesion of drug delivery systems is the turnover time. The turnover time for the buccal epithelium has been estimated to be 3–8 days compared to about 30 days for the skin . 4. Physiological opportunities for oral transmucosal drug deliveryAuthor: Viralkumar F. Patel, Fang Liu, Marc B. Brown
https://www.academia.edu/13483387/Transmucosal_delivery_systems_for_calcitonin_a_review
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http://europepmc.org/abstract/MED/10811300
Jul 01, 2000 · Researchers have studied different routes to deliver salmon calcitonin more effectively, including nasal, oral, vaginal and rectal delivery. These systems are designed to protect the polypeptide from the biological barriers that each delivery route imposes. Oil-based and polymer-based delivery systems are discussed.Author: Madeline Torres-Lugo, Nikolaos A Peppas
https://www.deepdyve.com/lp/elsevier/transmucosal-delivery-systems-for-calcitonin-a-review-q5vmcJDl5P
Jun 01, 2000 · Transmucosal delivery systems for calcitonin: a review Transmucosal delivery systems for calcitonin: a review Torres-Lugo, Madeline; Peppas, Nikolaos A 2000-06-01 00:00:00 The commercial availability of peptides and proteins and their advantages as therapeutic agents have been the basis for tremendous efforts in designing delivery systems for such agents.
https://www.researchgate.net/publication/232250506_Recent_trends_in_oral_transmucosal_drug_delivery_systems_An_emphasis_on_the_soft_palatal_route
Recent trends in oral transmucosal drug delivery systems: An emphasis on the soft palatal route Article · Literature Review (PDF Available) in Expert Opinion on Drug Delivery 9(6):629-647 ...
http://www.eurekaselect.com/114722/article
The transmucosal route includes oral, nasal, vaginal, and urethral and presents a challenge in the field of novel drug delivery technology. The oral transmucosal delivery, especially the buccal and sublingual routes have been explored successfully for a number of drugs in the last few decades with novel approaches emerging continuously.Author: Pooja Abhang, Munira Momin, Mayur Inamdar, Swapan Kar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680553/
Jul 15, 2019 · Non-invasive delivery of insulin was long considered the pinnacle of the drug delivery field, whereas today emphasis has switched to GLP-1 agonists and other peptides. This is not only because they are smaller and more amendable for transmucosal delivery, but also because they may have a higher therapeutic index.Author: Sam Maher, Luca Casettari, Lisbeth Illum
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