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https://dimensionsofdentalhygiene.com/article/oral-use-transmucosal-drug-delivery/
Transmucosal drug delivery may allow dental teams to offer minimal sedation and more comfortable local injections. It also requires less equipment than some delivery methods, making it a cost-effective alternative. Yet, while there are advantages to this modality, there are also restrictions to developing drugs for transmucosal delivery.
http://www.eurekaselect.com/114722/article
The transmucosal route includes oral, nasal, vaginal, and urethral and presents a challenge in the field of novel drug delivery technology. The oral transmucosal delivery, especially the buccal and sublingual routes have been explored successfully for a number of drugs in the last few decades with novel approaches emerging continuously.Author: Pooja Abhang, Munira Momin, Mayur Inamdar, Swapan Kar
https://www.contractpharma.com/issues/2013-01/view_features/transdermaltransmucosal-drug-delivery
Transmucosal Delivery Systems The body’s mucous membranes occur primarily in the mouth and the nose. Their permeability — estimated at four to 4000 times that of the epidermis — allows for the systemic uptake of drugs painlessly and at a steady rate of delivery, bypassing the stomach environment and first-pass liver metabolism. The Mouth
https://www.sciencedirect.com/science/article/pii/S0168365911000332
The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond the use of traditional dosage forms with novel approaches emerging continuously.Author: Viralkumar F. Patel, Fang Liu, Marc B. Brown
https://www.tapemark.com/blog/oral-transmucosal-drug-delivery-effective-methods
Transmucosal drug delivery is an alternative platform for dosing formulations through oral or nasal administration. To be effective, the drug needs to be delivered in a controlled way to accomplish steady dissemination into the body. This type of focused delivery happens when the drug stays dynamic within a defined region of the body.Location: 1685 Marthaler Lane, St. Paul, 55118, MN
https://aquestive.com/innovative-drug-delivery-pharmfilm/transmucosal-expertise/
Transmucosal Expertise Advancing drug delivery Despite the number of advantages associated with transmucosal drug delivery, the number of medicines delivered as buccal or sublingual formulations remains relatively low. We believe in the potential for improving medicines through transmucosal delivery and work to make the possibilities real. 1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680553/
Jul 15, 2019 · Non-invasive delivery of insulin was long considered the pinnacle of the drug delivery field, whereas today emphasis has switched to GLP-1 agonists and other peptides. This is not only because they are smaller and more amendable for transmucosal delivery, but also because they may have a higher therapeutic index.Author: Sam Maher, Luca Casettari, Lisbeth Illum
https://www.sciencedirect.com/science/article/pii/S0378517314003901
Oral transmucosal drug delivery (OTDD) may be defined as the administration of pharmaceutically active agents through the oral mucosa to achieve systemic effects. This route has several advantages over conventional oral drug delivery as it avoids the harsh acidic environment of the stomach and the enzymatic milieu of the small intestine.Author: Mohammed Sattar, Mohammed Sattar, Ossama M. Sayed, Ossama M. Sayed, Majella E. Lane
https://www.ukessays.com/essays/biology/advantages-of-transmucosal-route-biology-essay.php
ADVANTAGES OF TRANSMUCOSAL ROUTE: i) Oral mucosa is a region has a rich blood supply. ii) Drugs are absorbed from the oral cavity through the oral mucosa, and transported through the deep lingual or facial vein, internal jugular vein, and braciocephalic vein into the systemic circulation.
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