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https://www.sciencedirect.com/science/article/pii/S0301008219301340
Obtaining efficient drug delivery to the brain remains the biggest challenge for the development of therapeutics to treat diseases of the central nervous system. The main obstacle is the blood-brain barrier (BBB), which impedes the entrance of most molecules present in the systemic circulation, especially large molecule drugs and nanomedicines.Author: Kasper Bendix Johnsen, Annette Burkhart, Louiza Bohn Thomsen, Thomas Lars Andresen, Torben Moos
http://onlinelibrary.wiley.com/doi/10.1002/med.10008/abstract
Mar 26, 2002 · Conjugates of anticancer drugs with transferrin can significantly improve the selectivity and toxicity and overcome drug resistance, thereby leading to a better treatment. The coupling of DNA to transferrin via a polycation such as polylysine or via cationic liposomes can target and transfer of the extrogenous DNA particularly into proliferating cells through receptor-mediated endocytosis.
https://www.sciencedirect.com/topics/medicine-and-dentistry/transferrin
Transferrin has several advantages for targeted delivery to cancer cells. Human transferrin is nonimmunogenic; therefore, it can be safely delivered without causing toxicity. Transferrin-conjugated drugs have been shown to prevent cardiotoxicity and drug resistance (Singh, 1999). Transferrin has been used to successfully deliver many cancer drugs.
https://www.ncbi.nlm.nih.gov/pubmed/31376426
Jul 31, 2019 · Obtaining efficient drug delivery to the brain remains the biggest challenge for the development of therapeutics to treat diseases of the central nervous system. The main obstacle is the blood-brain barrier (BBB), which impedes the entrance of most molecules present in the systemic circulation, especially large molecule drugs and nanomedicines.Author: Kasper Bendix Johnsen, Annette Burkhart, Louiza Bohn Thomsen, Thomas Lars Andresen, Torben Moos
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(02)01989-2
May 01, 2002 · Transferrin receptor in brain drug delivery The delivery of therapeutic agents to the brain is severely limited by the low permeability of these agents to the brain capillary endothelial wall, which makes up the blood–brain barrier (BBB) in vivo .Author: Hongyan Li, Hongzhe Sun, Zhong Ming Qian
http://pharmrev.aspetjournals.org/content/54/4/561
Dec 01, 2002 · The coupling of DNA to transferrin via a polycation or liposome serves as a potential alternative to viral vector for gene therapy. Moreover, the OX26 monoclonal antibody against the rat transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain.Author: Zhong Ming Qian, Hongyan Li, Hongzhe Sun, Kwokping Ho
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500658/
The Polycefin family of naturally-derived polymeric drug delivery is another example [160, 171]. This type of vehicle is built by hierarchic conjugation chemistry of functional groups onto the scaffold of PMLA, a polycarboxy polyester obtained from the microorganism Physarum polycephalum.Author: Tracy R. Daniels, Ezequiel Bernabeu, Ezequiel Bernabeu, José A. Rodríguez, Shabnum Patel, Maggie Koz...
https://www.nature.com/articles/s41598-017-11220-1
Sep 04, 2017 · Drug delivery to the brain is hampered by the presence of the blood-brain barrier, which excludes most molecules from freely diffusing into the brain, and tightly regulates the active transport mechanisms that ensure sufficient delivery of nutrients to the brain parenchyma.Author: Kasper Bendix Johnsen, Kasper Bendix Johnsen, Annette Burkhart, Fredrik Melander, Paul Joseph Kempen...
https://link.springer.com/article/10.1007/s13346-018-0552-2
Jun 18, 2018 · Treatment of glioblastoma multiforme (GBM) is a predominant challenge in chemotherapy due to the existence of blood–brain barrier (BBB) which restricts delivery of chemotherapeutic agents to the brain together with the problem of drug penetration through hard parenchyma of the GBM.Author: Hira Choudhury, Manisha Pandey, Pei Xin Chin, Yee Lin Phang, Jeng Yuen Cheah, Shu Chien Ooi, Kit Kay...
https://onlinelibrary.wiley.com/doi/abs/10.1002/med.10008
Mar 26, 2002 · Therefore, transferrin has been thought as a “delivery system” for many beneficial and harmful metal ions into the cells. Transferrin has also be widely applied as a targeting ligand in the active targeting of anticancer agents, proteins, and genes to primary proliferating malignant cells that overexpress transferrin receptors.Author: Jon E. Chatterton, Abbot F. Clark
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