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https://www.onlinelibrary.wiley.com/doi/abs/10.1211/0022357001773797
To improve bioavailability and achieve a smoother plasma‐concentration profile as compared with oral administration, a matrix‐dispersion‐type transdermal delivery system was designed and developed for propranolol using different ratios of hydroxypropyl‐methylcellulose (HPMC) K4M, K15M and K100M.Author: P. R. P. Verma, Sunil S. Iyer
https://www.researchgate.net/publication/232052701_Transdermal_Delivery_of_Propranolol
Transdermal drug delivery system (TDDS) provides a means to sustain drug release as well as reduce the intensity of action and thus reduce the side effects associated with its oral therapy.
https://www.researchgate.net/publication/12600804_Controlled_Transdermal_Delivery_of_Propranolol_Using_HPMC_Matrices_Design_and_In-vitro_and_In-vivo_Evaluation
Abstract To improve bioavailability and achieve a smoother plasma-concentration profile as compared with oral administration, a matrix-dispersion-type transdermal delivery system was designed and...
https://www.deepdyve.com/lp/wiley/controlled-transdermal-delivery-of-propranolol-using-hpmc-matrices-iMk5CDsac4
Feb 01, 2000 · To improve bioavailability and achieve a smoother plasma‐concentration profile as compared with oral administration, a matrix‐dispersion‐type transdermal delivery system was designed and developed for propranolol using different ratios of hydroxypropyl‐methylcellulose (HPMC) K4M, K15M and K100M.
https://www.ijpsonline.com/articles/development-of-mesophasic-microreservoirbased-transdermal-drug-delivery-system-of-propranolol.html
Liquid crystals, transdermal, drug delivery, In vitro evaluation, propranolol Transdermal drug delivery system which releases drug at a zero order rate is now in most cases considered as an ideal system for maintaining constant drug levels.Author: LK Omray, S Kohli, AJ Khopade, S Patil, Asmita Gajbhiye, GP Agrawal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038280/
The result in fig. 2 indicate that the transdermal systems (LC and MMTS), release propranolol gradually throughout the 24 h study, this could be due to controlled release of drug from LC and controlled release and polymer matrix diffusion controlled process from the MMTS. The cumulative amount of propranolol released from MMTS was about 1.12 mg in 24 h.
https://manipal.pure.elsevier.com/en/publications/design-and-evaluation-of-matrix-diffusion-controlled-transdermal-
A matrix dispersion type transdermal drug delivery system of Diltiazem Hydrochloride was developed using different ratios of rosin with Eudragit RL PM and polyvinyl pyrrolidone. The patch prepared by the combination of rosin and polyvinyl pyrrolidone was not transparent one, and shows an uneven distribution of polyvinyl pyrrolidone, which may be due to the hydrophilic nature of polyvinyl pyrrolidone.Author: S.L. Prabu, A. Shirwaikar, A. Kumar, A. Jacob
http://www.iosrphr.org/papers/v2i5/Part_6/G0253137.pdf
Formulation and evaluation of transdermal patches of propranololhydrochloride. 32. of polymers in mixture of solvent, added required quantity of dibutyl phthalate to this mixture, and vertexed. Finally weighed quantity of propranolol hydrochloride added to the polymer solution and mixed well.
https://www.sciencedirect.com/science/article/pii/S0939641100000631
The transdermal matrices used were Propercuten-mite TTS, a propranolol-loaded adhesive hydrogel patch, based on a hydrophilic matrix composed of high molecular weight PVP (MW=750 000–1 000 000) and oligomeric short-chain PEG (MW=400). The drug and PVP were dissolved in a mixture of liquid PEG and ethanol (cosolvent).Author: Alexei L. Iordanskii, Mikhail M. Feldstein, Valery S. Markin, Jonathan Hadgraft, Nicolai A. Plate
https://www.sciencedirect.com/science/article/pii/0378517395043519
Both in vitro and in vivo drug delivery rates from the TTS hydrophilic diffusion matrix are controlled by the skin or membrane permeability and may be described by Fick's law. The contributions of various physicochemical determinants to the control of transdermal drug delivery kinetics are discussed.Author: M.M. Feldstein, V.N. Tohmakhchi, L.B. Malkhazov, A.E. Vasiliev, N.A. Platé
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